tetano
Editor, Senior Moderator
J Infect Dis
. 2021 Feb 19;jiab104.
doi: 10.1093/infdis/jiab104. Online ahead of print.
Susceptibility and Attenuated Transmissibility of SARS-CoV-2 in Domestic Cats
Linlin Bao[SUP] 1 2 [/SUP], Zhiqi Song[SUP] 1 2 [/SUP], Jing Xue[SUP] 1 2 [/SUP], Hong Gao[SUP] 1 2 [/SUP], Jiangning Liu[SUP] 1 2 [/SUP], Jie Wang[SUP] 1 2 [/SUP], Qian Guo[SUP] 2 [/SUP], Binbin Zhao[SUP] 1 2 [/SUP], Yajin Qu[SUP] 1 2 [/SUP], Feifei Qi[SUP] 1 2 [/SUP], Shuran Gong[SUP] 1 2 [/SUP], Mingya Liu[SUP] 1 2 [/SUP], Lv Qi[SUP] 1 2 [/SUP], Dan Li[SUP] 1 2 [/SUP], Yunlin Han[SUP] 1 2 [/SUP], Wenjie Zhao[SUP] 1 2 [/SUP], Shoulong Deng[SUP] 2 [/SUP], Yunpeng Liu[SUP] 2 [/SUP], Zhiguang Xiang[SUP] 2 [/SUP], Bochao Yang[SUP] 2 [/SUP], Wei Deng[SUP] 1 2 [/SUP], Haisheng Yu[SUP] 1 2 [/SUP], Zhe Cong[SUP] 1 2 [/SUP], Qiang Wei[SUP] 1 2 [/SUP], Jianguo Xu[SUP] 3 [/SUP], George F Gao[SUP] 4 [/SUP], Chuan Qin[SUP] 1 2 [/SUP]
Affiliations
Abstract
Domestic cats, an important companion animal, can be infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This has aroused concern regarding the ability of domestic cats to spread the virus that causes coronavirus disease 2019. We systematically demonstrated the pathogenesis and transmissibility of SARS-CoV-2 in cats. Serial passaging of the virus between cats dramatically attenuated the viral transmissibility, likely owing to variations of the amino acids in the receptor-binding domain sites of angiotensin-converting enzyme 2 between humans and cats. These findings provide insight into the transmissibility of SARS-CoV-2 in cats and provide information for protecting the health of humans and cats. Article Summary Line: Domestic cats are susceptible to SARS-CoV-2 and have attenuated transmissibility after serial passaging.
Keywords: COVID-19; SARS-CoV-2; cats; pathogenesis; susceptibility; transmissibility.
. 2021 Feb 19;jiab104.
doi: 10.1093/infdis/jiab104. Online ahead of print.
Susceptibility and Attenuated Transmissibility of SARS-CoV-2 in Domestic Cats
Linlin Bao[SUP] 1 2 [/SUP], Zhiqi Song[SUP] 1 2 [/SUP], Jing Xue[SUP] 1 2 [/SUP], Hong Gao[SUP] 1 2 [/SUP], Jiangning Liu[SUP] 1 2 [/SUP], Jie Wang[SUP] 1 2 [/SUP], Qian Guo[SUP] 2 [/SUP], Binbin Zhao[SUP] 1 2 [/SUP], Yajin Qu[SUP] 1 2 [/SUP], Feifei Qi[SUP] 1 2 [/SUP], Shuran Gong[SUP] 1 2 [/SUP], Mingya Liu[SUP] 1 2 [/SUP], Lv Qi[SUP] 1 2 [/SUP], Dan Li[SUP] 1 2 [/SUP], Yunlin Han[SUP] 1 2 [/SUP], Wenjie Zhao[SUP] 1 2 [/SUP], Shoulong Deng[SUP] 2 [/SUP], Yunpeng Liu[SUP] 2 [/SUP], Zhiguang Xiang[SUP] 2 [/SUP], Bochao Yang[SUP] 2 [/SUP], Wei Deng[SUP] 1 2 [/SUP], Haisheng Yu[SUP] 1 2 [/SUP], Zhe Cong[SUP] 1 2 [/SUP], Qiang Wei[SUP] 1 2 [/SUP], Jianguo Xu[SUP] 3 [/SUP], George F Gao[SUP] 4 [/SUP], Chuan Qin[SUP] 1 2 [/SUP]
Affiliations
- PMID: 33605423
- DOI: 10.1093/infdis/jiab104
Abstract
Domestic cats, an important companion animal, can be infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This has aroused concern regarding the ability of domestic cats to spread the virus that causes coronavirus disease 2019. We systematically demonstrated the pathogenesis and transmissibility of SARS-CoV-2 in cats. Serial passaging of the virus between cats dramatically attenuated the viral transmissibility, likely owing to variations of the amino acids in the receptor-binding domain sites of angiotensin-converting enzyme 2 between humans and cats. These findings provide insight into the transmissibility of SARS-CoV-2 in cats and provide information for protecting the health of humans and cats. Article Summary Line: Domestic cats are susceptible to SARS-CoV-2 and have attenuated transmissibility after serial passaging.
Keywords: COVID-19; SARS-CoV-2; cats; pathogenesis; susceptibility; transmissibility.