tetano
Editor, Senior Moderator
J Infect Dis
. 2022 Jul 7;jiac288.
doi: 10.1093/infdis/jiac288. Online ahead of print.
Single dose vaccination among infants and toddlers provides modest protection against influenza illness which wanes after 5 months
Abram L Wagner[SUP] 1 [/SUP], Nery Sanchez[SUP] 2 [/SUP], John Kubale[SUP] 1 [/SUP], Guillermina Kuan[SUP] 2 3 [/SUP], Lionel Gresh[SUP] 2 [/SUP], Roger Lopez[SUP] 2 4 [/SUP], Sergio Ojeda[SUP] 2 [/SUP], Eduardo Azziz-Baumgartner[SUP] 5 [/SUP], Angel Balmaseda[SUP] 2 4 [/SUP], Aubree Gordon[SUP] 1 [/SUP]
Affiliations
Abstract
In their first season of vaccination, young children are recommended 2 doses of influenza vaccine, but a two-dose schedule might be difficult to implement in many countries. Within a cohort study of 742 children aged 6 to <24 months in Managua, Nicaragua, this study estimated effectiveness of partial vaccination from 3 to 9 months post-vaccination. Vaccine effectiveness (VE) was 74% (95% CI: 24%, 91%) within 3 months and 55% (95% CI: 10%, 77%) within 4 months. There was not significant protection beyond 5 months. Partial vaccination might confer some benefits but should be followed by a second dose.
Keywords: child; cohort study; developing country; influenza vaccine; influenza virus.
. 2022 Jul 7;jiac288.
doi: 10.1093/infdis/jiac288. Online ahead of print.
Single dose vaccination among infants and toddlers provides modest protection against influenza illness which wanes after 5 months
Abram L Wagner[SUP] 1 [/SUP], Nery Sanchez[SUP] 2 [/SUP], John Kubale[SUP] 1 [/SUP], Guillermina Kuan[SUP] 2 3 [/SUP], Lionel Gresh[SUP] 2 [/SUP], Roger Lopez[SUP] 2 4 [/SUP], Sergio Ojeda[SUP] 2 [/SUP], Eduardo Azziz-Baumgartner[SUP] 5 [/SUP], Angel Balmaseda[SUP] 2 4 [/SUP], Aubree Gordon[SUP] 1 [/SUP]
Affiliations
- PMID: 35796722
- DOI: 10.1093/infdis/jiac288
Abstract
In their first season of vaccination, young children are recommended 2 doses of influenza vaccine, but a two-dose schedule might be difficult to implement in many countries. Within a cohort study of 742 children aged 6 to <24 months in Managua, Nicaragua, this study estimated effectiveness of partial vaccination from 3 to 9 months post-vaccination. Vaccine effectiveness (VE) was 74% (95% CI: 24%, 91%) within 3 months and 55% (95% CI: 10%, 77%) within 4 months. There was not significant protection beyond 5 months. Partial vaccination might confer some benefits but should be followed by a second dose.
Keywords: child; cohort study; developing country; influenza vaccine; influenza virus.