Giuseppe
Emeritus
J Infect Dis. 2009 May 5. [Epub ahead of print]
Risk Factors for Human Illness with Avian Influenza A (H5N1) Virus Infection in China.
Zhou L, Liao Q, Dong L, Huai Y, Bai T, Xiang N, Shu Y, Liu W, Wang S, Qin P, Wang M, Xing X, Lv J, Chen RY, Feng Z, Yang W, Uyeki TM, Yu H. - Office for Disease Control and Emergency Response and 2State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, and 3Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 4Wuhan Center for Disease Control and Prevention and 5Hubei Provincial Center for Disease Control and Prevention, Wuhan, and 6Guangzhou Center for Disease Control and Prevention, Guangzhou, China; 7National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; and 8Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Background.
In China, 30 human cases of avian influenza A (H5N1) virus infection were identified through July 2008. We conducted a retrospective case-control study to identify risk factors for influenza H5N1 disease in China.
Methods.
A questionnaire about potential influenza H5N1 exposures was administered to 28 patients with influenza H5N1 and to 134 randomly selected control subjects matched by age, sex, and location or to proxies. Conditional logistic regression analyses were performed.
Results.
Before their illness, patients living in urban areas had visited wet poultry markets, and patients living in rural areas had exposure to sick or dead backyard poultry. In multivariable analyses, independent risk factors for influenza H5N1 were direct contact with sick or dead poultry (odds ratio [OR], 506.6 [95% confidence interval {CI}, 15.7-16319.6]; [Formula: see text]), indirect exposure to sick or dead poultry (OR, 56.9 [95% CI, 4.3-745.6]; [Formula: see text]), and visiting a wet poultry market (OR, 15.4 [95% CI, 3.0-80.2]; [Formula: see text]).
Conclusions.
To prevent human influenza H5N1 in China, the level of education about avoiding direct or close exposures to sick or dead poultry should be increased, and interventions to prevent the spread of influenza H5N1 at live poultry markets should be implemented.
PMID: 19416076 [PubMed - as supplied by publisher]
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Risk Factors for Human Illness with Avian Influenza A (H5N1) Virus Infection in China.
Zhou L, Liao Q, Dong L, Huai Y, Bai T, Xiang N, Shu Y, Liu W, Wang S, Qin P, Wang M, Xing X, Lv J, Chen RY, Feng Z, Yang W, Uyeki TM, Yu H. - Office for Disease Control and Emergency Response and 2State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, and 3Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 4Wuhan Center for Disease Control and Prevention and 5Hubei Provincial Center for Disease Control and Prevention, Wuhan, and 6Guangzhou Center for Disease Control and Prevention, Guangzhou, China; 7National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; and 8Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Background.
In China, 30 human cases of avian influenza A (H5N1) virus infection were identified through July 2008. We conducted a retrospective case-control study to identify risk factors for influenza H5N1 disease in China.
Methods.
A questionnaire about potential influenza H5N1 exposures was administered to 28 patients with influenza H5N1 and to 134 randomly selected control subjects matched by age, sex, and location or to proxies. Conditional logistic regression analyses were performed.
Results.
Before their illness, patients living in urban areas had visited wet poultry markets, and patients living in rural areas had exposure to sick or dead backyard poultry. In multivariable analyses, independent risk factors for influenza H5N1 were direct contact with sick or dead poultry (odds ratio [OR], 506.6 [95% confidence interval {CI}, 15.7-16319.6]; [Formula: see text]), indirect exposure to sick or dead poultry (OR, 56.9 [95% CI, 4.3-745.6]; [Formula: see text]), and visiting a wet poultry market (OR, 15.4 [95% CI, 3.0-80.2]; [Formula: see text]).
Conclusions.
To prevent human influenza H5N1 in China, the level of education about avoiding direct or close exposures to sick or dead poultry should be increased, and interventions to prevent the spread of influenza H5N1 at live poultry markets should be implemented.
PMID: 19416076 [PubMed - as supplied by publisher]
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