tetano
Editor, Senior Moderator
J Infect Dis
. 2024 Apr 4:jiae171.
doi: 10.1093/infdis/jiae171. Online ahead of print. Respiratory syncytial virus vs. Influenza virus infection: mortality and morbidity comparison over 7 epidemic seasons in an elderly population
C Recto[SUP] 1 [/SUP], S Fourati[SUP] 2 [/SUP], M Khellaf[SUP] 3 [/SUP], J-M Pawlotsky[SUP] 2 [/SUP], N De Prost[SUP] 4 5 [/SUP], H Diakonoff[SUP] 6 [/SUP], C Donadio[SUP] 7 [/SUP], L Pouga[SUP] 2 [/SUP], C de Tymowski[SUP] 8 [/SUP], C Kassasseya[SUP] 3 [/SUP]
Affiliations
Background: Respiratory syncytial virus (RSV) infection is gaining interest due to the recent development of vaccines, but it is still misdiagnosed in the elderly. The primary objective was to compare all-cause mortality at day 30. Secondary objectives were to compare clinical presentation, and rates of consolidative pneumonia, hospitalization, and intensive care unit (ICU) admission.
Methods: Single-centre retrospective study conducted in a French university hospital during 7 epidemic seasons. All patients aged ≥75 years were included.
Results: 558 patients were included: 125 with RSV and 433 with Influenza. Median age was 84.8 years. RSV patients had more respiratory symptoms (wheezing, dyspnea), whereas Influenza patients had more general symptoms (fever, asthenia, myalgia). Consolidative pneumonia (28.8% vs. 17.2%; p = 0.004), hospitalization rates (83.2% vs. 70%; p = 0.003), ICU admissions (7.2% vs. 3.0%; p = 0.034) and length of stay (9 days [2-16] vs. 5 days [0-12]; p = 0.002), were higher in the RSV group. Mortality rates at day 30 were comparable (RSV 9.6%, Influenza 9.7%; p = 0.973).
Conclusions: This study included the largest cohort of RSV-infected patients aged over 75, documented in-depth thus far. RSV shares a comparable mortality rate with Influenza but is associated with higher rates of consolidative pneumonia, hospitalization, ICU admissions, and extended hospital stays.
Keywords: Influenza virus; Respiratory syncytial virus; elderly; lower tract respiratory infection (LTRI); mortality; pneumonia.
. 2024 Apr 4:jiae171.
doi: 10.1093/infdis/jiae171. Online ahead of print. Respiratory syncytial virus vs. Influenza virus infection: mortality and morbidity comparison over 7 epidemic seasons in an elderly population
C Recto[SUP] 1 [/SUP], S Fourati[SUP] 2 [/SUP], M Khellaf[SUP] 3 [/SUP], J-M Pawlotsky[SUP] 2 [/SUP], N De Prost[SUP] 4 5 [/SUP], H Diakonoff[SUP] 6 [/SUP], C Donadio[SUP] 7 [/SUP], L Pouga[SUP] 2 [/SUP], C de Tymowski[SUP] 8 [/SUP], C Kassasseya[SUP] 3 [/SUP]
Affiliations
- PMID: 38574192
- DOI: 10.1093/infdis/jiae171
Background: Respiratory syncytial virus (RSV) infection is gaining interest due to the recent development of vaccines, but it is still misdiagnosed in the elderly. The primary objective was to compare all-cause mortality at day 30. Secondary objectives were to compare clinical presentation, and rates of consolidative pneumonia, hospitalization, and intensive care unit (ICU) admission.
Methods: Single-centre retrospective study conducted in a French university hospital during 7 epidemic seasons. All patients aged ≥75 years were included.
Results: 558 patients were included: 125 with RSV and 433 with Influenza. Median age was 84.8 years. RSV patients had more respiratory symptoms (wheezing, dyspnea), whereas Influenza patients had more general symptoms (fever, asthenia, myalgia). Consolidative pneumonia (28.8% vs. 17.2%; p = 0.004), hospitalization rates (83.2% vs. 70%; p = 0.003), ICU admissions (7.2% vs. 3.0%; p = 0.034) and length of stay (9 days [2-16] vs. 5 days [0-12]; p = 0.002), were higher in the RSV group. Mortality rates at day 30 were comparable (RSV 9.6%, Influenza 9.7%; p = 0.973).
Conclusions: This study included the largest cohort of RSV-infected patients aged over 75, documented in-depth thus far. RSV shares a comparable mortality rate with Influenza but is associated with higher rates of consolidative pneumonia, hospitalization, ICU admissions, and extended hospital stays.
Keywords: Influenza virus; Respiratory syncytial virus; elderly; lower tract respiratory infection (LTRI); mortality; pneumonia.