tetano
Editor, Senior Moderator
J Infect Dis
. 2020 Dec 22;jiaa776.
doi: 10.1093/infdis/jiaa776. Online ahead of print.
Pneumonia following symptomatic influenza infection among Nicaraguan children before and after introduction of the pneumococcal conjugate vaccine
John Kubale[SUP] 1 [/SUP], Angel Balmaseda[SUP] 2 [/SUP], Nery Sanchez[SUP] 3 [/SUP], Roger Lopez[SUP] 2 [/SUP], Lionel Gresh[SUP] 3 [/SUP], Sergio Ojeda[SUP] 3 [/SUP], Eva Harris[SUP] 4 [/SUP], Guillermina Kuan[SUP] 5 [/SUP], Jon Zelner[SUP] 1 [/SUP], Aubree Gordon[SUP] 1 [/SUP]
Affiliations
Abstract
Influenza is associated with primary viral and secondary bacterial pneumonias; however, the dynamics of this relationship in populations with varied levels of pneumococcal vaccination remain unclear. We conducted nested matched case-control studies in two prospective cohorts of Nicaraguan children aged 2-14 years: one before PCV introduction (2008-2010) and one following its introduction and near universal adoption (2011-2018). The association between influenza and pneumonia was similar in both cohorts. Participants with influenza (across types/subtypes) had higher odds of developing pneumonia in the month following influenza infection. These findings underscore the importance of considering influenza in interventions to reduce global pneumonia burden.
Keywords: Nicaragua; child health; global health; influenza; pneumonia.
. 2020 Dec 22;jiaa776.
doi: 10.1093/infdis/jiaa776. Online ahead of print.
Pneumonia following symptomatic influenza infection among Nicaraguan children before and after introduction of the pneumococcal conjugate vaccine
John Kubale[SUP] 1 [/SUP], Angel Balmaseda[SUP] 2 [/SUP], Nery Sanchez[SUP] 3 [/SUP], Roger Lopez[SUP] 2 [/SUP], Lionel Gresh[SUP] 3 [/SUP], Sergio Ojeda[SUP] 3 [/SUP], Eva Harris[SUP] 4 [/SUP], Guillermina Kuan[SUP] 5 [/SUP], Jon Zelner[SUP] 1 [/SUP], Aubree Gordon[SUP] 1 [/SUP]
Affiliations
- PMID: 33351091
- DOI: 10.1093/infdis/jiaa776
Abstract
Influenza is associated with primary viral and secondary bacterial pneumonias; however, the dynamics of this relationship in populations with varied levels of pneumococcal vaccination remain unclear. We conducted nested matched case-control studies in two prospective cohorts of Nicaraguan children aged 2-14 years: one before PCV introduction (2008-2010) and one following its introduction and near universal adoption (2011-2018). The association between influenza and pneumonia was similar in both cohorts. Participants with influenza (across types/subtypes) had higher odds of developing pneumonia in the month following influenza infection. These findings underscore the importance of considering influenza in interventions to reduce global pneumonia burden.
Keywords: Nicaragua; child health; global health; influenza; pneumonia.