Giuseppe
Emeritus
J Infect Dis. 2009 Aug 15;200(4):510-515.
Parameters of Fulminant Acute Respiratory Distress Syndrome and Avian Influenza (H5N1) Infection in Vietnamese Children.
Kawachi S, Luong ST, Shigematsu M, Furuya H, Phung TT, Phan PH, Nunoi H, Nguyen LT, Suzuki K. Department of Immunology and 2Infectious Disease Surveillance Center, National Institute of Infectious Diseases, and 3Division of Anaesthesia, Surgical Operation Department, International Medical Center of Japan, Tokyo, 4Basic Clinical Science and Public Health, Tokai University School of Medicine, Isehara, 5Division of Pediatrics, Department of Reproductive and Developmental Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, and 6Inflammation Program, Department of Immunology, Chiba University Graduate School of Medicine, Chiba, Japan; and 7National Hospital of Pediatrics, Hanoi, Vietnam.
A clinical picture of patients with acute respiratory distress syndrome (ARDS) induced by highly pathogenic avian influenza A (H5N1) has been reported. We reviewed 37 sets of clinical data for pediatric patients with ARDS at the National Hospital of Pediatrics (Hanoi, Vietnam); 12 patients with H5N1-positive and 25 with H5N1-negative ARDS were enrolled. The H5N1-negative patients had a clinical picture and mortality rate similar to that for the pediatric ARDS patients. However, the H5N1-positive patients had ARDS with normal ventilation capacity at the time of hospital admission, then rapidly proceeded to severe respiratory failure. The survival probability and days until final outcome in groups of H5N1-positive ([Formula: see text]) vs. H5N1-negative ([Formula: see text]) patients were 17% versus 52% and [Formula: see text] days (median, 11 days) versus [Formula: see text] days (median, 22 days), respectively. Our observations clarified the clinical picture of H5N1-induced fulminant ARDS and also confirmed that relatively older age ( approximately 6 years of age), high fever at onset, and leukopenia and/or thrombocytopenia at the time of hospital admission are risk parameters for H5N1-induced fulminant ARDS.
PMID: 19591579 [PubMed - as supplied by publisher]
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Parameters of Fulminant Acute Respiratory Distress Syndrome and Avian Influenza (H5N1) Infection in Vietnamese Children.
Kawachi S, Luong ST, Shigematsu M, Furuya H, Phung TT, Phan PH, Nunoi H, Nguyen LT, Suzuki K. Department of Immunology and 2Infectious Disease Surveillance Center, National Institute of Infectious Diseases, and 3Division of Anaesthesia, Surgical Operation Department, International Medical Center of Japan, Tokyo, 4Basic Clinical Science and Public Health, Tokai University School of Medicine, Isehara, 5Division of Pediatrics, Department of Reproductive and Developmental Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, and 6Inflammation Program, Department of Immunology, Chiba University Graduate School of Medicine, Chiba, Japan; and 7National Hospital of Pediatrics, Hanoi, Vietnam.
A clinical picture of patients with acute respiratory distress syndrome (ARDS) induced by highly pathogenic avian influenza A (H5N1) has been reported. We reviewed 37 sets of clinical data for pediatric patients with ARDS at the National Hospital of Pediatrics (Hanoi, Vietnam); 12 patients with H5N1-positive and 25 with H5N1-negative ARDS were enrolled. The H5N1-negative patients had a clinical picture and mortality rate similar to that for the pediatric ARDS patients. However, the H5N1-positive patients had ARDS with normal ventilation capacity at the time of hospital admission, then rapidly proceeded to severe respiratory failure. The survival probability and days until final outcome in groups of H5N1-positive ([Formula: see text]) vs. H5N1-negative ([Formula: see text]) patients were 17% versus 52% and [Formula: see text] days (median, 11 days) versus [Formula: see text] days (median, 22 days), respectively. Our observations clarified the clinical picture of H5N1-induced fulminant ARDS and also confirmed that relatively older age ( approximately 6 years of age), high fever at onset, and leukopenia and/or thrombocytopenia at the time of hospital admission are risk parameters for H5N1-induced fulminant ARDS.
PMID: 19591579 [PubMed - as supplied by publisher]
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