tetano
Editor, Senior Moderator
J Infect Dis
. 2022 Aug 29;jiac357.
doi: 10.1093/infdis/jiac357. Online ahead of print.
Interactions between Severe Acute Respiratory Syndrome Coronavirus 2 Replication and Major Respiratory Viruses in Human nasal Epithelium
Pizzorno Andrés[SUP] 1 [/SUP], Padey Blandine[SUP] 1 2 [/SUP], Dulière Victoria[SUP] 1 3 [/SUP], Mouton William[SUP] 1 4 [/SUP], Oliva Justine[SUP] 1 [/SUP], Emilie Laurent[SUP] 1 3 [/SUP], Milesi Cedrine[SUP] 1 [/SUP], Lina Bruno[SUP] 1 [/SUP], Traversier Aurelien[SUP] 1 3 [/SUP], Julien Thomas[SUP] 1 3 [/SUP], Trouillet Assant Sophie[SUP] 1 4 [/SUP], Rosa Calatrava Manuel[SUP] 1 3 [/SUP], Terrier Olivier[SUP] 1 [/SUP]
Affiliations
Abstract
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), along with extensive non-pharmacological interventions, have profoundly altered the epidemiology of major respiratory viruses. Some studies have described virus-virus interactions, particularly manifested by viral interference mechanisms at different scales. Still, our knowledge of the mutual interactions between SARS-CoV-2 and other respiratory viruses remains incomplete. Here, we studied the interactions between SARS-CoV-2 and several respiratory viruses (influenza, RSV, hMPV, and hRV) in a reconstituted human epithelial airway model, exploring different scenarios affecting the sequence and timing of co-infections. We show that the virus type and the sequence of infections are key parameters of virus-virus interactions, having the impact of primary infections on the regulation of the immune response a determinant role in the outcome of secondary infections.
Keywords: Human Metapneumovirus; Human Rhinovirus; Respiratory syncytial virus; SARS-CoV-2; influenza virus; virus-virus interactions.
. 2022 Aug 29;jiac357.
doi: 10.1093/infdis/jiac357. Online ahead of print.
Interactions between Severe Acute Respiratory Syndrome Coronavirus 2 Replication and Major Respiratory Viruses in Human nasal Epithelium
Pizzorno Andrés[SUP] 1 [/SUP], Padey Blandine[SUP] 1 2 [/SUP], Dulière Victoria[SUP] 1 3 [/SUP], Mouton William[SUP] 1 4 [/SUP], Oliva Justine[SUP] 1 [/SUP], Emilie Laurent[SUP] 1 3 [/SUP], Milesi Cedrine[SUP] 1 [/SUP], Lina Bruno[SUP] 1 [/SUP], Traversier Aurelien[SUP] 1 3 [/SUP], Julien Thomas[SUP] 1 3 [/SUP], Trouillet Assant Sophie[SUP] 1 4 [/SUP], Rosa Calatrava Manuel[SUP] 1 3 [/SUP], Terrier Olivier[SUP] 1 [/SUP]
Affiliations
- PMID: 36031537
- DOI: 10.1093/infdis/jiac357
Abstract
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), along with extensive non-pharmacological interventions, have profoundly altered the epidemiology of major respiratory viruses. Some studies have described virus-virus interactions, particularly manifested by viral interference mechanisms at different scales. Still, our knowledge of the mutual interactions between SARS-CoV-2 and other respiratory viruses remains incomplete. Here, we studied the interactions between SARS-CoV-2 and several respiratory viruses (influenza, RSV, hMPV, and hRV) in a reconstituted human epithelial airway model, exploring different scenarios affecting the sequence and timing of co-infections. We show that the virus type and the sequence of infections are key parameters of virus-virus interactions, having the impact of primary infections on the regulation of the immune response a determinant role in the outcome of secondary infections.
Keywords: Human Metapneumovirus; Human Rhinovirus; Respiratory syncytial virus; SARS-CoV-2; influenza virus; virus-virus interactions.