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Glucose-6-Phosphate Dehydrogenase Deficiency Enhances Human Coronavirus 229E Infection
Yi-Hsuan Wu, Ching-Ping Tseng, Mei-Ling Cheng, ****-Yao Ho, Shin-Ru Shih, Daniel Tsun-Yee Chiu
The Journal of Infectious Diseases, Volume 197, Issue 6, 15 March 2008, Pages 812–816, https://doi.org/10.1086/528377
Published:
15 March 2008
Article history
Abstract
The host cellular environment is a key determinant of pathogen infectivity. Viral gene expression and viral particle production of glucose-6-phosphate dehydrogenase (G6PD)–deficient and G6PD-knockdown cells were much higher than their counterparts when human coronavirus (HCoV) 229E was applied at 0.1 multiplicity of infection. These phenomena were correlated with increased oxidant production. Accordingly, ectopic expression of G6PD in G6PD-deficient cells or addition of antioxidant (such as α-lipoic acid) to G6PD-knockdown cells attenuated the increased susceptibility to HCoV 229E infection. All experimental data indicated that oxidative stress in host cells is an important factor in HCoV 229E infectivity
https://academic.oup.com/jid/article...searchresult=1
Glucose-6-Phosphate Dehydrogenase Deficiency Enhances Human Coronavirus 229E Infection
Yi-Hsuan Wu, Ching-Ping Tseng, Mei-Ling Cheng, ****-Yao Ho, Shin-Ru Shih, Daniel Tsun-Yee Chiu
The Journal of Infectious Diseases, Volume 197, Issue 6, 15 March 2008, Pages 812–816, https://doi.org/10.1086/528377
Published:
15 March 2008
Article history
Abstract
The host cellular environment is a key determinant of pathogen infectivity. Viral gene expression and viral particle production of glucose-6-phosphate dehydrogenase (G6PD)–deficient and G6PD-knockdown cells were much higher than their counterparts when human coronavirus (HCoV) 229E was applied at 0.1 multiplicity of infection. These phenomena were correlated with increased oxidant production. Accordingly, ectopic expression of G6PD in G6PD-deficient cells or addition of antioxidant (such as α-lipoic acid) to G6PD-knockdown cells attenuated the increased susceptibility to HCoV 229E infection. All experimental data indicated that oxidative stress in host cells is an important factor in HCoV 229E infectivity
https://academic.oup.com/jid/article...searchresult=1