tetano
Editor, Senior Moderator
J Infect Dis
. 2020 Dec 24;jiaa789.
doi: 10.1093/infdis/jiaa789. Online ahead of print.
Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic
Jeffrey R Strich[SUP] 1 2 [/SUP], Marcos J Ramos-Benitez[SUP] 1 [/SUP], Davide Randazzo[SUP] 3 [/SUP], Sydney R Stein[SUP] 1 [/SUP], Ashley Babyak[SUP] 1 [/SUP], Richard T Davey[SUP] 4 [/SUP], Anthony F Suffredini[SUP] 1 [/SUP], Richard W Childs[SUP] 2 5 [/SUP], Daniel S Chertow[SUP] 1 2 4 [/SUP]
Affiliations
Abstract
Neutrophil extracellular traps (NETs) contribute to immunothrombosis and have been associated with mortality in Coronavirus Disease 2019 (COVID-19). We stimulated donor neutrophils with plasma from patients with COVID-19 and demonstrate that R406 can abrogate the release of NETs. These data provide evidence for how fostamatinib may mitigate neutrophil-associated mechanisms contributing to COVID-19 immunopathogenesis.
Keywords: COVID-19; Neutrophil extracellular traps; fostamatinib; immunothrombosis.
. 2020 Dec 24;jiaa789.
doi: 10.1093/infdis/jiaa789. Online ahead of print.
Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic
Jeffrey R Strich[SUP] 1 2 [/SUP], Marcos J Ramos-Benitez[SUP] 1 [/SUP], Davide Randazzo[SUP] 3 [/SUP], Sydney R Stein[SUP] 1 [/SUP], Ashley Babyak[SUP] 1 [/SUP], Richard T Davey[SUP] 4 [/SUP], Anthony F Suffredini[SUP] 1 [/SUP], Richard W Childs[SUP] 2 5 [/SUP], Daniel S Chertow[SUP] 1 2 4 [/SUP]
Affiliations
- PMID: 33367731
- DOI: 10.1093/infdis/jiaa789
Abstract
Neutrophil extracellular traps (NETs) contribute to immunothrombosis and have been associated with mortality in Coronavirus Disease 2019 (COVID-19). We stimulated donor neutrophils with plasma from patients with COVID-19 and demonstrate that R406 can abrogate the release of NETs. These data provide evidence for how fostamatinib may mitigate neutrophil-associated mechanisms contributing to COVID-19 immunopathogenesis.
Keywords: COVID-19; Neutrophil extracellular traps; fostamatinib; immunothrombosis.