Giuseppe
Emeritus
Evidence of Person-to-Person Transmission of Oseltamivir-Resistant Pandemic Influenza A(H1N1) 2009 Virus in a Hematology Unit (J Infect Dis., abstract, edited)
[Source: Journal of Infectious Diseases, full PDF document (LINK). Abstract, edited.]
Evidence of Person-to-Person Transmission of Oseltamivir-Resistant Pandemic Influenza A(H1N1) 2009 Virus in a Hematology Unit
Catherine Moore,1 Monica Galiano,7 Angie Lackenby,7 Tamer Abdelrahman,1 Rosemary Barnes,4 Meirion R. Evans,3,5 Christopher Fegan,2 Susannah Froude,1 Mark Hastings,1 Steven Knapper,6 Emma Litt,2 Nicola Price,1 Roland Salmon,3 Mark Temple,3 and Eleri Davies1
1Public Health Wales Microbiology, Public Health Wales NHS Trust, Cardiff, UK;
2Hematology Department, University Hospital of Wales, Heath Park;
3Communicable Disease Surveillance Centre, Public Health Wales NHS Trust, Temple of Peace and Health, Cathays Park, Cardiff, UK;
4Medical Microbiology, Department of Infection, Immunity and Biochemistry, Cardiff University School of Medicine, Cardiff, UK;
5Department of Primary Care and Public Health, Cardiff University, Cardiff, UK;
6Department of Hematology, Cardiff University, Cardiff, UK
7Respiratory Virus Unit, Virus Reference Division, Centre for Infection, Health Protection Agency, Colindale, London, United Kingdom
Received 19 May 2010; accepted 3 August 2010.
Potential conflicts of interest: none reported.
Reprints or correspondence: Dr Eleri Davies, Public Health Wales Microbiology Cardiff, Public Health Wales NHS Trust University Hospital of Wales, Heath Park, Cardiff CF14 4XW, United Kingdom (email: eleri.davies4@wales.nhs.uk)
The Journal of Infectious Diseases 2011;203:18?24
Copyright. The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org.
1537-6613/2011/2031-0001$15.00
DOI: 10.1093/infdis/jiq007
We describe the first confirmed person-to-person transmission of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus that occurred in a hematology unit in the United Kingdom. Eleven cases of (H1N1) 2009 virus infection were identified, of which, ten were related as shown by sequence analysis of the hemagglutinin and neuraminidase genes. H275Y analysis demonstrated that 8 of 10 case patients had oseltamivir-resistant virus, with 4 of 8 case patients infected by direct transmission of resistant virus. Zanamivir should be considered as first-line therapy for influenza in patients with lymphopenic hematological conditions and uptake of influenza vaccination encouraged to further reduce the number of susceptible individuals.
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[Source: Journal of Infectious Diseases, full PDF document (LINK). Abstract, edited.]
Evidence of Person-to-Person Transmission of Oseltamivir-Resistant Pandemic Influenza A(H1N1) 2009 Virus in a Hematology Unit
Catherine Moore,1 Monica Galiano,7 Angie Lackenby,7 Tamer Abdelrahman,1 Rosemary Barnes,4 Meirion R. Evans,3,5 Christopher Fegan,2 Susannah Froude,1 Mark Hastings,1 Steven Knapper,6 Emma Litt,2 Nicola Price,1 Roland Salmon,3 Mark Temple,3 and Eleri Davies1
1Public Health Wales Microbiology, Public Health Wales NHS Trust, Cardiff, UK;
2Hematology Department, University Hospital of Wales, Heath Park;
3Communicable Disease Surveillance Centre, Public Health Wales NHS Trust, Temple of Peace and Health, Cathays Park, Cardiff, UK;
4Medical Microbiology, Department of Infection, Immunity and Biochemistry, Cardiff University School of Medicine, Cardiff, UK;
5Department of Primary Care and Public Health, Cardiff University, Cardiff, UK;
6Department of Hematology, Cardiff University, Cardiff, UK
7Respiratory Virus Unit, Virus Reference Division, Centre for Infection, Health Protection Agency, Colindale, London, United Kingdom
Received 19 May 2010; accepted 3 August 2010.
Potential conflicts of interest: none reported.
Reprints or correspondence: Dr Eleri Davies, Public Health Wales Microbiology Cardiff, Public Health Wales NHS Trust University Hospital of Wales, Heath Park, Cardiff CF14 4XW, United Kingdom (email: eleri.davies4@wales.nhs.uk)
The Journal of Infectious Diseases 2011;203:18?24
Copyright. The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org.
1537-6613/2011/2031-0001$15.00
DOI: 10.1093/infdis/jiq007
We describe the first confirmed person-to-person transmission of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus that occurred in a hematology unit in the United Kingdom. Eleven cases of (H1N1) 2009 virus infection were identified, of which, ten were related as shown by sequence analysis of the hemagglutinin and neuraminidase genes. H275Y analysis demonstrated that 8 of 10 case patients had oseltamivir-resistant virus, with 4 of 8 case patients infected by direct transmission of resistant virus. Zanamivir should be considered as first-line therapy for influenza in patients with lymphopenic hematological conditions and uptake of influenza vaccination encouraged to further reduce the number of susceptible individuals.
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