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Editor, Senior Moderator
J Infect Dis. (2013) doi: 10.1093/infdis/jit372 First published online: August 1, 2013
Estimation of the association between antibody titers and protection against confirmed influenza virus infection in children
Sophia Ng1,
Vicky J. Fang1,
Dennis K. M. Ip1,
Kwok-Hung Chan2,
Gabriel M. Leung1,
J. S. Malik Peiris1,3 and
Benjamin J. Cowling1
+ Author Affiliations
1School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China
2Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China
3Centre for Influenza Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China
Corresponding author: Dr Benjamin J. Cowling, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong. Tel: +852 3906 2011; Fax: +852 3520 1945; email: bcowling@hku.hk
Alternate corresponding author if corresponding author is not available: Prof. Gabriel M Leung, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong. Tel: +852 3906 2000; Fax: +852 3520 1945; email: gmleung@hku.hk
Abstract
Antibody titers measured by hemagglutination inhibition (HAI) correlate with protection against influenza virus infection, and are used to specify criteria for vaccine licensure. In a randomized controlled trial of seasonal influenza vaccination in 773 children 6-17y, we estimated that HAI titers of 1:40 against A(H1N1)pdm09 and B(Victoria-lineage) were associated with 48% (95% confidence interval, CI: 30%-62%) and 55% (95%CI: 32%-70%) protection against PCR-confirmed infection with each strain. Our analysis accounted for waning in antibody titers over time, and could be particularly useful in settings where influenza activity is delayed or prolonged relative to measurement of antibody titers.
http://jid.oxfordjournals.org/content/early/2013/08/01/infdis.jit372.abstract
Estimation of the association between antibody titers and protection against confirmed influenza virus infection in children
Sophia Ng1,
Vicky J. Fang1,
Dennis K. M. Ip1,
Kwok-Hung Chan2,
Gabriel M. Leung1,
J. S. Malik Peiris1,3 and
Benjamin J. Cowling1
+ Author Affiliations
1School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China
2Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China
3Centre for Influenza Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China
Corresponding author: Dr Benjamin J. Cowling, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong. Tel: +852 3906 2011; Fax: +852 3520 1945; email: bcowling@hku.hk
Alternate corresponding author if corresponding author is not available: Prof. Gabriel M Leung, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong. Tel: +852 3906 2000; Fax: +852 3520 1945; email: gmleung@hku.hk
Abstract
Antibody titers measured by hemagglutination inhibition (HAI) correlate with protection against influenza virus infection, and are used to specify criteria for vaccine licensure. In a randomized controlled trial of seasonal influenza vaccination in 773 children 6-17y, we estimated that HAI titers of 1:40 against A(H1N1)pdm09 and B(Victoria-lineage) were associated with 48% (95% confidence interval, CI: 30%-62%) and 55% (95%CI: 32%-70%) protection against PCR-confirmed infection with each strain. Our analysis accounted for waning in antibody titers over time, and could be particularly useful in settings where influenza activity is delayed or prolonged relative to measurement of antibody titers.
http://jid.oxfordjournals.org/content/early/2013/08/01/infdis.jit372.abstract