Giuseppe
Emeritus
Dual Resistance to Adamantanes and Oseltamivir Among Seasonal Influenza A(H1N1) Viruses: 2008?2010 (J Infect Dis., abstract, edited)
[Source: Journal of Infectious Diseases, full PDF document (LINK). Abstract, edited.]
Dual Resistance to Adamantanes and Oseltamivir Among Seasonal Influenza A(H1N1) Viruses: 2008?2010
Tiffany G. Sheu,1,2 Alicia M. Fry,1 Rebecca J. Garten,1 Varough M. Deyde,1 Thein Shwe,3 Lesley Bullion,4 Patrick J. Peebles,1 Yan Li,5 Alexander I. Klimov,1 and Larisa V. Gubareva 1
1 Influenza Division, Centers for Disease Control and Prevention and
2 Battelle Memorial Institute, Atlanta, Georgia;
3 West Virginia Bureau of Public Health, Charleston, West Virginia;
4 Texas Department of State Health Services, Austin, Texas; and
5 National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
Received 3 May 2010; accepted 20 July 2010.
Conflicts of interests: none reported.
The findings and conclusions of this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.
Reprints or correspondence: Dr Larisa V. Gubareva, 1600 Clifton Rd, Mailstop G-16,, Atlanta, GA 30333. (lgubareva@cdc.gov).
Journal of Infectious Diseases 2011;203(1):13?17
Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2011.
1537-6613/2011/2031-0001$15.00
DOI: 10.1093/infdis/jiq005
Two distinct genetic clades of seasonal influenza A(H1N1) viruses have cocirculated in the recent seasons: clade 2B oseltamivir-resistant and adamantane-susceptible viruses, and clade 2C viruses that are resistant to adamantanes and susceptible to oseltamivir. We tested seasonal influenza A(H1N1) viruses collected in 2008-2010 from the United States and globally for resistance to antivirals approved by the Food and Drug Administration. We report 28 viruses with both adamantane and oseltamivir (dual) resistance from 5 countries belonging to 4 distinct genotypes. Because of limited options for antiviral treatment, emergence of dual-resistant influenza viruses poses a public health concern, and their circulation needs to be closely monitored.
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[Source: Journal of Infectious Diseases, full PDF document (LINK). Abstract, edited.]
Dual Resistance to Adamantanes and Oseltamivir Among Seasonal Influenza A(H1N1) Viruses: 2008?2010
Tiffany G. Sheu,1,2 Alicia M. Fry,1 Rebecca J. Garten,1 Varough M. Deyde,1 Thein Shwe,3 Lesley Bullion,4 Patrick J. Peebles,1 Yan Li,5 Alexander I. Klimov,1 and Larisa V. Gubareva 1
1 Influenza Division, Centers for Disease Control and Prevention and
2 Battelle Memorial Institute, Atlanta, Georgia;
3 West Virginia Bureau of Public Health, Charleston, West Virginia;
4 Texas Department of State Health Services, Austin, Texas; and
5 National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
Received 3 May 2010; accepted 20 July 2010.
Conflicts of interests: none reported.
The findings and conclusions of this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.
Reprints or correspondence: Dr Larisa V. Gubareva, 1600 Clifton Rd, Mailstop G-16,, Atlanta, GA 30333. (lgubareva@cdc.gov).
Journal of Infectious Diseases 2011;203(1):13?17
Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2011.
1537-6613/2011/2031-0001$15.00
DOI: 10.1093/infdis/jiq005
Two distinct genetic clades of seasonal influenza A(H1N1) viruses have cocirculated in the recent seasons: clade 2B oseltamivir-resistant and adamantane-susceptible viruses, and clade 2C viruses that are resistant to adamantanes and susceptible to oseltamivir. We tested seasonal influenza A(H1N1) viruses collected in 2008-2010 from the United States and globally for resistance to antivirals approved by the Food and Drug Administration. We report 28 viruses with both adamantane and oseltamivir (dual) resistance from 5 countries belonging to 4 distinct genotypes. Because of limited options for antiviral treatment, emergence of dual-resistant influenza viruses poses a public health concern, and their circulation needs to be closely monitored.
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