tetano
Editor, Senior Moderator
J Infect Dis
. 2020 Aug 12;jiaa518.
doi: 10.1093/infdis/jiaa518. Online ahead of print.
COVID 19 Vaccines: Should we fear ADE?
Scott B Halstead[SUP] 1 [/SUP], Leah Katzelnick[SUP] 2 3 [/SUP]
Affiliations
Abstract
Might COVID 19 vaccines sensitize humans to antibody dependent enhanced (ADE) breakthrough infections? This outcome is unlikely because coronavirus diseases in humans lack the clinical, epidemiological, biological or pathological attributes of ADE disease exemplified by the dengue viruses (DENV). In contrast to DENV, SARS and MERS CoVs predominantly infect respiratory epithelium, not macrophages. Severe disease centers on older persons with pre-existing conditions and not young infants or individuals with previous coronavirus infections. Live virus challenge of animals given SARS or MERS vaccines has resulted in vaccine hypersensitivity reactions (VAH), similar to those in humans given inactivated measles or respiratory syncytial virus vaccines. Safe and effective COVID 19 vaccines must avoid VAH.
Keywords: SARS CoV-1; SARS CoV-2; T cells; antibody; antibody dependent enhancement (ADE); coronavirus; dengue; dengue hemorrhagic fever; hypersensitivity; immunopathology; vaccine; vaccine adverse events.
. 2020 Aug 12;jiaa518.
doi: 10.1093/infdis/jiaa518. Online ahead of print.
COVID 19 Vaccines: Should we fear ADE?
Scott B Halstead[SUP] 1 [/SUP], Leah Katzelnick[SUP] 2 3 [/SUP]
Affiliations
- PMID: 32785649
- DOI: 10.1093/infdis/jiaa518
Abstract
Might COVID 19 vaccines sensitize humans to antibody dependent enhanced (ADE) breakthrough infections? This outcome is unlikely because coronavirus diseases in humans lack the clinical, epidemiological, biological or pathological attributes of ADE disease exemplified by the dengue viruses (DENV). In contrast to DENV, SARS and MERS CoVs predominantly infect respiratory epithelium, not macrophages. Severe disease centers on older persons with pre-existing conditions and not young infants or individuals with previous coronavirus infections. Live virus challenge of animals given SARS or MERS vaccines has resulted in vaccine hypersensitivity reactions (VAH), similar to those in humans given inactivated measles or respiratory syncytial virus vaccines. Safe and effective COVID 19 vaccines must avoid VAH.
Keywords: SARS CoV-1; SARS CoV-2; T cells; antibody; antibody dependent enhancement (ADE); coronavirus; dengue; dengue hemorrhagic fever; hypersensitivity; immunopathology; vaccine; vaccine adverse events.