tetano
Editor, Senior Moderator
J Infect Dis
. 2021 Mar 23;jiab161.
doi: 10.1093/infdis/jiab161. Online ahead of print.
Coronavirus Occurrence in the HIVE Cohort of Michigan Households: Reinfection frequency and serologic responses to seasonal and SARS coronaviruses
Joshua G Petrie[SUP] 1 [/SUP], Latifa A Bazzi[SUP] 1 [/SUP], Adrian B McDermott[SUP] 2 [/SUP], Dean Follmann[SUP] 2 [/SUP], Dominic Esposito[SUP] 3 [/SUP], Christian Hatcher[SUP] 2 [/SUP], Allyson Mateja[SUP] 4 [/SUP], Sandeep R Narpala[SUP] 2 [/SUP], Sarah E O'Connell[SUP] 2 [/SUP], Emily T Martin[SUP] 1 [/SUP], Arnold S Monto[SUP] 1 [/SUP]
Affiliations
Abstract
Background: We investigated frequency of reinfection with seasonal coronaviruses (HCoV) and serum antibody response following infection over 8 years in the Household Influenza Vaccine Evaluation cohort.
Methods: Households were followed annually for identification of acute respiratory illness with RT-PCR confirmed HCoV infection. Serum collected before and at two time points post infection were tested using a multiplex binding assay to quantify antibody to seasonal, SARS-CoV-1, and SARS-CoV-2 spike proteins and SARS-CoV-2 spike sub-domains and N protein.
Results: Of 3418 participants, 40% were followed for ?3years. A total of 1004 HCoV infections were documented; 303 (30%) were reinfections of any HCoV type. The number of HCoV infections ranged from 1 to 13 per individual. The mean time to reinfection with the same type was estimated at 983 days for 229E, 578 days for HKU1, 615 days for OC43, and 711 days for NL63. Binding antibody levels to seasonal HCoVs were high, with little increase post-infection, and were maintained over time. Homologous, pre-infection antibody levels did not significantly correlate with odds of infection, and there was little cross response to SARS-CoV-2 proteins.
Conclusions: Reinfection with seasonal HCoVs is frequent. Binding anti-spike protein antibodies do not correlate with protection from seasonal HCoV infection.
Keywords: COVID-19; SARS-CoV-2; antibody; correlates of protection; household cohort; immunity; reinfection; seasonal coronavirus; serology; waning.
. 2021 Mar 23;jiab161.
doi: 10.1093/infdis/jiab161. Online ahead of print.
Coronavirus Occurrence in the HIVE Cohort of Michigan Households: Reinfection frequency and serologic responses to seasonal and SARS coronaviruses
Joshua G Petrie[SUP] 1 [/SUP], Latifa A Bazzi[SUP] 1 [/SUP], Adrian B McDermott[SUP] 2 [/SUP], Dean Follmann[SUP] 2 [/SUP], Dominic Esposito[SUP] 3 [/SUP], Christian Hatcher[SUP] 2 [/SUP], Allyson Mateja[SUP] 4 [/SUP], Sandeep R Narpala[SUP] 2 [/SUP], Sarah E O'Connell[SUP] 2 [/SUP], Emily T Martin[SUP] 1 [/SUP], Arnold S Monto[SUP] 1 [/SUP]
Affiliations
- PMID: 33755731
- DOI: 10.1093/infdis/jiab161
Abstract
Background: We investigated frequency of reinfection with seasonal coronaviruses (HCoV) and serum antibody response following infection over 8 years in the Household Influenza Vaccine Evaluation cohort.
Methods: Households were followed annually for identification of acute respiratory illness with RT-PCR confirmed HCoV infection. Serum collected before and at two time points post infection were tested using a multiplex binding assay to quantify antibody to seasonal, SARS-CoV-1, and SARS-CoV-2 spike proteins and SARS-CoV-2 spike sub-domains and N protein.
Results: Of 3418 participants, 40% were followed for ?3years. A total of 1004 HCoV infections were documented; 303 (30%) were reinfections of any HCoV type. The number of HCoV infections ranged from 1 to 13 per individual. The mean time to reinfection with the same type was estimated at 983 days for 229E, 578 days for HKU1, 615 days for OC43, and 711 days for NL63. Binding antibody levels to seasonal HCoVs were high, with little increase post-infection, and were maintained over time. Homologous, pre-infection antibody levels did not significantly correlate with odds of infection, and there was little cross response to SARS-CoV-2 proteins.
Conclusions: Reinfection with seasonal HCoVs is frequent. Binding anti-spike protein antibodies do not correlate with protection from seasonal HCoV infection.
Keywords: COVID-19; SARS-CoV-2; antibody; correlates of protection; household cohort; immunity; reinfection; seasonal coronavirus; serology; waning.