tetano
Editor, Senior Moderator
J Infect Dis
. 2020 Aug 19;jiaa528.
doi: 10.1093/infdis/jiaa528. Online ahead of print.
Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19
Christophe Guervilly[SUP] 1 2 [/SUP], Stephane Burtey[SUP] 3 4 [/SUP], Florence Sabatier[SUP] 4 5 6 [/SUP], Rapha?l Cauchois[SUP] 4 7 [/SUP], Guillaume Lano[SUP] 3 4 [/SUP], Evelyne Abdili[SUP] 5 [/SUP], Florence Daviet[SUP] 3 [/SUP], Laurent Arnaud[SUP] 5 [/SUP], Philippe Brunet[SUP] 3 4 [/SUP], Sami Hraiech[SUP] 1 2 [/SUP], No?mie Jourde-Chiche[SUP] 3 4 [/SUP], Marie Koubi[SUP] 7 [/SUP], Romaric Lacroix[SUP] 4 5 [/SUP], L?a Pietri[SUP] 8 [/SUP], Ya?l Berda[SUP] 5 [/SUP], Thomas Robert[SUP] 3 4 [/SUP], Clara Degioanni[SUP] 6 [/SUP], M?lanie Velier[SUP] 4 5 [/SUP], Laurent Papazian[SUP] 1 2 [/SUP], Gilles Kaplanski[SUP] 4 7 [/SUP], Fran?oise Dignat-George[SUP] 4 5 [/SUP]
Affiliations
Abstract
Beside the commonly described pulmonary expression of the coronavirus disease 2019 (COVID-19), major vascular events have been reported. The objective of this study was to investigate whether increased levels of circulating endothelial cells (CEC) might be associated with severe forms of COVID-19. Ninety-nine patients with COVID-19 were enrolled in this retrospective study. Patients in the intensive care units (ICU) had significantly higher CEC counts than non-ICU patients and the extent of endothelial injury was correlated with putative markers of disease severity and inflammatory cytokines. Altogether, these data provide in vivo evidence that endothelial injury is a key feature of COVID-19.
Keywords: COVID-19; Circulating endothelial cells; endothelial injury.
. 2020 Aug 19;jiaa528.
doi: 10.1093/infdis/jiaa528. Online ahead of print.
Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19
Christophe Guervilly[SUP] 1 2 [/SUP], Stephane Burtey[SUP] 3 4 [/SUP], Florence Sabatier[SUP] 4 5 6 [/SUP], Rapha?l Cauchois[SUP] 4 7 [/SUP], Guillaume Lano[SUP] 3 4 [/SUP], Evelyne Abdili[SUP] 5 [/SUP], Florence Daviet[SUP] 3 [/SUP], Laurent Arnaud[SUP] 5 [/SUP], Philippe Brunet[SUP] 3 4 [/SUP], Sami Hraiech[SUP] 1 2 [/SUP], No?mie Jourde-Chiche[SUP] 3 4 [/SUP], Marie Koubi[SUP] 7 [/SUP], Romaric Lacroix[SUP] 4 5 [/SUP], L?a Pietri[SUP] 8 [/SUP], Ya?l Berda[SUP] 5 [/SUP], Thomas Robert[SUP] 3 4 [/SUP], Clara Degioanni[SUP] 6 [/SUP], M?lanie Velier[SUP] 4 5 [/SUP], Laurent Papazian[SUP] 1 2 [/SUP], Gilles Kaplanski[SUP] 4 7 [/SUP], Fran?oise Dignat-George[SUP] 4 5 [/SUP]
Affiliations
- PMID: 32812049
- DOI: 10.1093/infdis/jiaa528
Abstract
Beside the commonly described pulmonary expression of the coronavirus disease 2019 (COVID-19), major vascular events have been reported. The objective of this study was to investigate whether increased levels of circulating endothelial cells (CEC) might be associated with severe forms of COVID-19. Ninety-nine patients with COVID-19 were enrolled in this retrospective study. Patients in the intensive care units (ICU) had significantly higher CEC counts than non-ICU patients and the extent of endothelial injury was correlated with putative markers of disease severity and inflammatory cytokines. Altogether, these data provide in vivo evidence that endothelial injury is a key feature of COVID-19.
Keywords: COVID-19; Circulating endothelial cells; endothelial injury.