Giuseppe
Emeritus
Avian Influenza A(H5N1) Viruses Can Directly Infect and Replicate in Human Gut Tissues. (J Infect Dis., abstract, edited)
[Source: US National Library of Medicine, LINK. EDITED.]
J Infect Dis. 2010 Mar 8. [Epub ahead of print]
Avian Influenza A(H5N1) Viruses Can Directly Infect and Replicate in Human Gut Tissues.
Shu Y, Li CK, Li Z, Gao R, Liang Q, Zhang Y, Dong L, Zhou J, Dong J, Wang D, Wen L, Wang M, Bai T, Li D, Dong X, Yu H, Yang W, Wang Y, Feng Z, McMichael AJ, Xu XN. - State Key Laboratory for Infectious Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, 2Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China; 3MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
The human respiratory tract is a major site of avian influenza A(H5N1) infection. However, many humans infected with H5N1 present with gastrointestinal tract symptoms, suggesting that this may also be a target for the virus. In this study, we demonstrated that the human gut expresses abundant avian H5N1 receptors, is readily infected ex vivo by the H5N1 virus, and produces infectious viral particles in organ culture. An autopsy colonic sample from an H5N1-infected patient showed evidence of viral antigen expression in the gut epithelium. Our results provide the first evidence, to our knowledge, that H5N1 can directly target human gut tissues.
PMID: 20210629 [PubMed - as supplied by publisher]
J Infect Dis. 2010 Mar 8. [Epub ahead of print]
Avian Influenza A(H5N1) Viruses Can Directly Infect and Replicate in Human Gut Tissues.
Shu Y, Li CK, Li Z, Gao R, Liang Q, Zhang Y, Dong L, Zhou J, Dong J, Wang D, Wen L, Wang M, Bai T, Li D, Dong X, Yu H, Yang W, Wang Y, Feng Z, McMichael AJ, Xu XN. - State Key Laboratory for Infectious Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, 2Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China; 3MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
The human respiratory tract is a major site of avian influenza A(H5N1) infection. However, many humans infected with H5N1 present with gastrointestinal tract symptoms, suggesting that this may also be a target for the virus. In this study, we demonstrated that the human gut expresses abundant avian H5N1 receptors, is readily infected ex vivo by the H5N1 virus, and produces infectious viral particles in organ culture. An autopsy colonic sample from an H5N1-infected patient showed evidence of viral antigen expression in the gut epithelium. Our results provide the first evidence, to our knowledge, that H5N1 can directly target human gut tissues.
PMID: 20210629 [PubMed - as supplied by publisher]