tetano
Editor, Senior Moderator
J Infect Dev Ctries
. 2022 Mar 31;16(3):409-417.
doi: 10.3855/jidc.15845.
Prognostic factors for COVID-19 patients
Uğur Önal[SUP] 1 [/SUP], Özge Aydın Güçlü[SUP] 2 [/SUP], Halis Akalın[SUP] 3 [/SUP], Nilüfer Aylin Acet Öztürk[SUP] 2 [/SUP], Cihan Semet[SUP] 3 [/SUP], Ezgi Demirdöğen[SUP] 2 [/SUP], Aslı Görek Dilektaşlı[SUP] 2 [/SUP], İmran Sağlık[SUP] 4 [/SUP], Esra Kazak[SUP] 3 [/SUP], Güven Özkaya[SUP] 5 [/SUP], Funda Coşkun[SUP] 2 [/SUP], Dane Ediger[SUP] 2 [/SUP], Yasemin Heper[SUP] 3 [/SUP], Ahmet Ursavaş[SUP] 2 [/SUP], Emel Yılmaz[SUP] 3 [/SUP], Esra Uzaslan[SUP] 2 [/SUP], Mehmet Karadağ[SUP] 2 [/SUP]
Affiliations
Abstract
Introduction: Determining prognostic factors in patients with coronavirus disease (COVID-19) can have great impact on treatment planning and follow-up strategies. Herein, we aimed to evaluate prognostic factors and clinical scores for confirmed COVID-19 patients in a tertiary-care hospital in the Bursa region of Turkey.
Methodology: Patients who had been diagnosed with COVID-19 microbiologically and/or radiologically between March and October 2020 in a tertiary-care university hospital were enrolled retrospectively. Adult patients (≥ 18 years) with a clinical spectrum of moderate, severe, or critical illness were included. The dependent variable was 30-day mortality and logistic regression analysis was used to evaluate any variables with a significant p value (< 0.05) in univariate analysis.
Results: A total of 257 patients were included in the study. The mortality rate (30-day) was 14.4%. In logistic regression analysis, higher scores on sequential organ failure assessment (SOFA) (p < 0.001, odds ratio (OR) = 1.86, 95% CI = 1.42-2.45) and CURB-65 pneumonia severity criteria (p = 0.001, OR = 2.60, 95% CI = 1.47-4.57) were found to be significant in predicting mortality at admission. In deceased patients, there were also significant differences between the baseline, day-3, day-7, and day-14 results of D-dimer (p = 0.01), ferritin (p = 0.042), leukocyte (p = 0.019), and neutrophil (p = 0.007) counts.
Conclusions: In our study of COVID-19 patients, we found that high SOFA and CURB-65 scores on admission were associated with increased mortality. In addition, D-dimer, ferritin, leukocyte and neutrophil counts significantly increased after admission in patients who died.
Keywords: COVID-19; CURB-65; SOFA; prognostic factors.
. 2022 Mar 31;16(3):409-417.
doi: 10.3855/jidc.15845.
Prognostic factors for COVID-19 patients
Uğur Önal[SUP] 1 [/SUP], Özge Aydın Güçlü[SUP] 2 [/SUP], Halis Akalın[SUP] 3 [/SUP], Nilüfer Aylin Acet Öztürk[SUP] 2 [/SUP], Cihan Semet[SUP] 3 [/SUP], Ezgi Demirdöğen[SUP] 2 [/SUP], Aslı Görek Dilektaşlı[SUP] 2 [/SUP], İmran Sağlık[SUP] 4 [/SUP], Esra Kazak[SUP] 3 [/SUP], Güven Özkaya[SUP] 5 [/SUP], Funda Coşkun[SUP] 2 [/SUP], Dane Ediger[SUP] 2 [/SUP], Yasemin Heper[SUP] 3 [/SUP], Ahmet Ursavaş[SUP] 2 [/SUP], Emel Yılmaz[SUP] 3 [/SUP], Esra Uzaslan[SUP] 2 [/SUP], Mehmet Karadağ[SUP] 2 [/SUP]
Affiliations
- PMID: 35404844
- DOI: 10.3855/jidc.15845
Abstract
Introduction: Determining prognostic factors in patients with coronavirus disease (COVID-19) can have great impact on treatment planning and follow-up strategies. Herein, we aimed to evaluate prognostic factors and clinical scores for confirmed COVID-19 patients in a tertiary-care hospital in the Bursa region of Turkey.
Methodology: Patients who had been diagnosed with COVID-19 microbiologically and/or radiologically between March and October 2020 in a tertiary-care university hospital were enrolled retrospectively. Adult patients (≥ 18 years) with a clinical spectrum of moderate, severe, or critical illness were included. The dependent variable was 30-day mortality and logistic regression analysis was used to evaluate any variables with a significant p value (< 0.05) in univariate analysis.
Results: A total of 257 patients were included in the study. The mortality rate (30-day) was 14.4%. In logistic regression analysis, higher scores on sequential organ failure assessment (SOFA) (p < 0.001, odds ratio (OR) = 1.86, 95% CI = 1.42-2.45) and CURB-65 pneumonia severity criteria (p = 0.001, OR = 2.60, 95% CI = 1.47-4.57) were found to be significant in predicting mortality at admission. In deceased patients, there were also significant differences between the baseline, day-3, day-7, and day-14 results of D-dimer (p = 0.01), ferritin (p = 0.042), leukocyte (p = 0.019), and neutrophil (p = 0.007) counts.
Conclusions: In our study of COVID-19 patients, we found that high SOFA and CURB-65 scores on admission were associated with increased mortality. In addition, D-dimer, ferritin, leukocyte and neutrophil counts significantly increased after admission in patients who died.
Keywords: COVID-19; CURB-65; SOFA; prognostic factors.
