tetano
Editor, Senior Moderator
J Infect Dev Ctries
. 2021 Mar 7;15(2):224-229.
doi: 10.3855/jidc.13922.
Arrhythmia Risk Profile and Ventricular Repolarization Indices in COVID-19 Patients: A Systematic Review and Meta-Analysis
Alexander Edo Tondas[SUP] 1 [/SUP], Rido Mulawarman[SUP] 2 [/SUP], Monica Trifitriana[SUP] 2 [/SUP], Siti Nurmaini[SUP] 3 [/SUP], Irfannuddin Irfannuddin[SUP] 2 [/SUP]
Affiliations
Abstract
Introduction: Coronavirus disease 2019 (COVID-19) has been associated with cardiac arrhythmias. Several electrocardiographic markers have been used to predict the risk of arrhythmia in patients with COVID-19. We aim to investigate the electrocardiographic (ECG) ventricular repolarization indices in patients with COVID-19.
Methodology: We performed a comprehensive systematic literature search from PubMed, EuropePMC, SCOPUS, Cochrane Central Database, and Google Scholar Preprint Servers. The primary endpoints of this search were: Tp-e (T-peak-to-T-end) interval, QTd (QT dispersion), and Tp-e/QTc ratio in patients with newly diagnosed COVID-19 from inception up until August 2020.
Results: There were a total of 241 patients from 2 studies. Meta-analysis showed that Tp-e/QTc ratio was higher in COVID-19 group (mean difference 0.02 [0.01, 0.02], p < 0.001; I2: 18%,). Tp-e interval was more prolonged in COVID-19 group (mean difference 7.76 [3.11, 12.41], p < 0.001; I2: 80%) compared to control group. QT dispersion (QTd) also was increased in COVID-19 group (mean difference 1.22 [0.61, 1.83], p < 0.001 ; I2:30%).
Conclusions: Several electrocardiographic markers including Tp-e/QTc, Tp-e interval, and QTd are significantly increased in patients with COVID-19.
Keywords: COVID-19; ECG; SARS-CoV-2; T-peak-to-T-end; arrhythmia; meta-analysis; ventricular repolarization.
. 2021 Mar 7;15(2):224-229.
doi: 10.3855/jidc.13922.
Arrhythmia Risk Profile and Ventricular Repolarization Indices in COVID-19 Patients: A Systematic Review and Meta-Analysis
Alexander Edo Tondas[SUP] 1 [/SUP], Rido Mulawarman[SUP] 2 [/SUP], Monica Trifitriana[SUP] 2 [/SUP], Siti Nurmaini[SUP] 3 [/SUP], Irfannuddin Irfannuddin[SUP] 2 [/SUP]
Affiliations
- PMID: 33690204
- DOI: 10.3855/jidc.13922
Abstract
Introduction: Coronavirus disease 2019 (COVID-19) has been associated with cardiac arrhythmias. Several electrocardiographic markers have been used to predict the risk of arrhythmia in patients with COVID-19. We aim to investigate the electrocardiographic (ECG) ventricular repolarization indices in patients with COVID-19.
Methodology: We performed a comprehensive systematic literature search from PubMed, EuropePMC, SCOPUS, Cochrane Central Database, and Google Scholar Preprint Servers. The primary endpoints of this search were: Tp-e (T-peak-to-T-end) interval, QTd (QT dispersion), and Tp-e/QTc ratio in patients with newly diagnosed COVID-19 from inception up until August 2020.
Results: There were a total of 241 patients from 2 studies. Meta-analysis showed that Tp-e/QTc ratio was higher in COVID-19 group (mean difference 0.02 [0.01, 0.02], p < 0.001; I2: 18%,). Tp-e interval was more prolonged in COVID-19 group (mean difference 7.76 [3.11, 12.41], p < 0.001; I2: 80%) compared to control group. QT dispersion (QTd) also was increased in COVID-19 group (mean difference 1.22 [0.61, 1.83], p < 0.001 ; I2:30%).
Conclusions: Several electrocardiographic markers including Tp-e/QTc, Tp-e interval, and QTd are significantly increased in patients with COVID-19.
Keywords: COVID-19; ECG; SARS-CoV-2; T-peak-to-T-end; arrhythmia; meta-analysis; ventricular repolarization.