tetano
Editor, Senior Moderator
J Infect
. 2021 Aug 19;S0163-4453(21)00415-1.
doi: 10.1016/j.jinf.2021.08.026. Online ahead of print.
Cytokinelevels in sputum, not serum, may be more helpful 1 for indicating the damage in the lung and the prognosis of severe COVID-19 - A Case Series
Changsong Wang[SUP] 1 [/SUP], Kai Kang[SUP] 2 [/SUP], Xiuwen Lan[SUP] 3 [/SUP], Dongsheng Fei[SUP] 2 [/SUP], Qian Wang[SUP] 3 [/SUP], Xianyong Li[SUP] 2 [/SUP], Yang Chong[SUP] 2 [/SUP], Yan Gao[SUP] 4 [/SUP], Huaiquan Wang[SUP] 5 [/SUP], Xueting Li[SUP] 3 [/SUP], Mingyan Zhao[SUP] 6 [/SUP], Kaijiang Yu[SUP] 7 [/SUP]
Affiliations
Abstract
Purpose: To describe the relationship between the severity of lung damage and cytokine levels in sputum, bronchoalveolar lavage fluid (BALF), serum.
Method: Eight severe patients infected with coronavirus disease 2019 (COVID-19) were admitted and their cytokines and chest computed tomography (CT) were analyzed.
Results: Compared with in serum, IL-6 and TNF-α in sputum and in BALF show more directly reflect the severity of COVID-19 critical patients. The gradient ratio of IL-6 levels may predict the prognosis of severe patients.
Conclusion: Cytokine levels in the sputum may be more helpful for indicating lung damage. Local intervention through the respiratory tract is expected to benefit patients with severe COVID-19.
Keywords: BALF; COVID-19; IL-6; TNF-α; sputum.
. 2021 Aug 19;S0163-4453(21)00415-1.
doi: 10.1016/j.jinf.2021.08.026. Online ahead of print.
Cytokinelevels in sputum, not serum, may be more helpful 1 for indicating the damage in the lung and the prognosis of severe COVID-19 - A Case Series
Changsong Wang[SUP] 1 [/SUP], Kai Kang[SUP] 2 [/SUP], Xiuwen Lan[SUP] 3 [/SUP], Dongsheng Fei[SUP] 2 [/SUP], Qian Wang[SUP] 3 [/SUP], Xianyong Li[SUP] 2 [/SUP], Yang Chong[SUP] 2 [/SUP], Yan Gao[SUP] 4 [/SUP], Huaiquan Wang[SUP] 5 [/SUP], Xueting Li[SUP] 3 [/SUP], Mingyan Zhao[SUP] 6 [/SUP], Kaijiang Yu[SUP] 7 [/SUP]
Affiliations
- PMID: 34419557
- DOI: 10.1016/j.jinf.2021.08.026
Abstract
Purpose: To describe the relationship between the severity of lung damage and cytokine levels in sputum, bronchoalveolar lavage fluid (BALF), serum.
Method: Eight severe patients infected with coronavirus disease 2019 (COVID-19) were admitted and their cytokines and chest computed tomography (CT) were analyzed.
Results: Compared with in serum, IL-6 and TNF-α in sputum and in BALF show more directly reflect the severity of COVID-19 critical patients. The gradient ratio of IL-6 levels may predict the prognosis of severe patients.
Conclusion: Cytokine levels in the sputum may be more helpful for indicating lung damage. Local intervention through the respiratory tract is expected to benefit patients with severe COVID-19.
Keywords: BALF; COVID-19; IL-6; TNF-α; sputum.