tetano
Editor, Senior Moderator
J Infect Chemother
. 2023 Oct 14:S1341-321X(23)00250-7.
doi: 10.1016/j.jiac.2023.10.005. Online ahead of print. Two cases of systemic capillary leak syndrome associated with COVID-19 in Japan
Atsushi Kosaka[SUP] 1 [/SUP], Takao Goto[SUP] 2 [/SUP], Takuya Washino[SUP] 2 [/SUP], Naoya Sakamoto[SUP] 2 [/SUP], Sentaro Iwabuchi[SUP] 2 [/SUP], Fukumi Nakamura-Uchiyama[SUP] 2 [/SUP]
Affiliations
Systemic Capillary Leak Syndrome (SCLS) is a rare disease that causes severe distributive shock provoked by infection or vaccination. SCLS is clinically diagnosed by a triad of distributive shock, paradoxical hemoconcentration, and hypoalbuminemia. SCLS associated with coronavirus disease (COVID-19) in adults has not been reported yet in Japan. Case 1: A 61-year-old woman with fever, sore throat, headache, and muscle pain was admitted to our emergency department with suspected COVID-19. She had been diagnosed with SCLS 3 years earlier. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen and polymerase chain reaction (PCR) tests were negative at admission. She went into shock in the emergency department and was treated for septic shock. The following day, the SARS-CoV-2 PCR test was positive. She did not respond to fluid resuscitation and catecholamine and finally died. Case 2: A 58-year-old man was admitted to our hospital for de-saturation due to COVID-19. He got into shock on day 3. SCLS was suspected, and 5 g of intravenous immunoglobulin and 5% albumin were administered for sepsis treatment. He responded to the aggressive fluid therapy within 48 h and was finally discharged. COVID-19 can trigger SCLS, and early recognition of SCLS is crucial for survival. Primary care physicians should consider SCLS when they observe distributive shock and paradoxical hemoconcentration deviations from the natural course of COVID-19.
Keywords: COVID-19; Distributive shock; Paradoxical hemoconcentration; Systemic capillary leak syndrome.
. 2023 Oct 14:S1341-321X(23)00250-7.
doi: 10.1016/j.jiac.2023.10.005. Online ahead of print. Two cases of systemic capillary leak syndrome associated with COVID-19 in Japan
Atsushi Kosaka[SUP] 1 [/SUP], Takao Goto[SUP] 2 [/SUP], Takuya Washino[SUP] 2 [/SUP], Naoya Sakamoto[SUP] 2 [/SUP], Sentaro Iwabuchi[SUP] 2 [/SUP], Fukumi Nakamura-Uchiyama[SUP] 2 [/SUP]
Affiliations
- PMID: 37844737
- DOI: 10.1016/j.jiac.2023.10.005
Systemic Capillary Leak Syndrome (SCLS) is a rare disease that causes severe distributive shock provoked by infection or vaccination. SCLS is clinically diagnosed by a triad of distributive shock, paradoxical hemoconcentration, and hypoalbuminemia. SCLS associated with coronavirus disease (COVID-19) in adults has not been reported yet in Japan. Case 1: A 61-year-old woman with fever, sore throat, headache, and muscle pain was admitted to our emergency department with suspected COVID-19. She had been diagnosed with SCLS 3 years earlier. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen and polymerase chain reaction (PCR) tests were negative at admission. She went into shock in the emergency department and was treated for septic shock. The following day, the SARS-CoV-2 PCR test was positive. She did not respond to fluid resuscitation and catecholamine and finally died. Case 2: A 58-year-old man was admitted to our hospital for de-saturation due to COVID-19. He got into shock on day 3. SCLS was suspected, and 5 g of intravenous immunoglobulin and 5% albumin were administered for sepsis treatment. He responded to the aggressive fluid therapy within 48 h and was finally discharged. COVID-19 can trigger SCLS, and early recognition of SCLS is crucial for survival. Primary care physicians should consider SCLS when they observe distributive shock and paradoxical hemoconcentration deviations from the natural course of COVID-19.
Keywords: COVID-19; Distributive shock; Paradoxical hemoconcentration; Systemic capillary leak syndrome.