tetano
Editor, Senior Moderator
J Infect Chemother
. 2025 Feb 26:102666.
doi: 10.1016/j.jiac.2025.102666. Online ahead of print. The Relationship Between Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Epidemic and Acute Myocardial Infarction: A Self-Controlled Case Series Study
Jun Suzuki[SUP] 1 [/SUP], Tomoki Mizuno[SUP] 2 [/SUP], Shota Takahashi[SUP] 3 [/SUP], Haruka Imai[SUP] 1 [/SUP], Hideya Itagaki[SUP] 4 [/SUP], Tomohiro Akaba[SUP] 5 [/SUP], Makiko Yoshida[SUP] 6 [/SUP], Shiro Endo[SUP] 7 [/SUP]
Affiliations
Background: The coronavirus disease 2019 (COVID-19) pandemic has led to various complications, including cardiovascular events. Despite the widespread impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant in 2022, no studies have evaluated the relationship between the Omicron variant epidemic and acute myocardial infarction (AMI).
Methods: We utilized a Japanese claims database to identify patients diagnosed with COVID-19 between January 1, 2022, and December 31, 2022. We also identified patients who developed AMI within 90 days before and after their COVID-19 diagnosis. A self-controlled case series (SCCS) analysis evaluated the incidence rate ratio (IRR) for AMI.
Results: Of the 360,589 patients with COVID-19, 759 were diagnosed with AMI. Excluding the day of exposure, the SCCS analysis showed an IRR for AMI of 6.65 (95% confidence interval [CI]: 4.66-9.48, P<0.001) for the 1st week, 1.90 (95% CI: 1.05-3.50, P=0.03) for the 2nd week, and 0.95 (95% CI: 0.52-1.72, P=0.87) for the 3rd and 4th weeks following COVID-19. Including the day of exposure, the IRR was 77.4 (95% CI: 63.2-94.9, P<0.001) for the 1st week, 1.90 (95% CI: 1.05-3.50, P=0.03) for the 2nd week, and 0.95 (95% CI: 0.52-1.72, P=0.87) for the 3rd and 4th weeks following COVID-19.
Conclusions: This study showed that the SARS-CoV-2 Omicron variant epidemic increased AMI incidence. These findings highlight AMI as a COVID-19 characteristic, emphasize the importance of SARS-CoV-2 vaccination, and underline the need for continued vigilance, even with variant changes.
Keywords: COVID-19; acute myocardial infarction; epidemic; omicron variant.
. 2025 Feb 26:102666.
doi: 10.1016/j.jiac.2025.102666. Online ahead of print. The Relationship Between Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Epidemic and Acute Myocardial Infarction: A Self-Controlled Case Series Study
Jun Suzuki[SUP] 1 [/SUP], Tomoki Mizuno[SUP] 2 [/SUP], Shota Takahashi[SUP] 3 [/SUP], Haruka Imai[SUP] 1 [/SUP], Hideya Itagaki[SUP] 4 [/SUP], Tomohiro Akaba[SUP] 5 [/SUP], Makiko Yoshida[SUP] 6 [/SUP], Shiro Endo[SUP] 7 [/SUP]
Affiliations
- PMID: 40021005
- DOI: 10.1016/j.jiac.2025.102666
Background: The coronavirus disease 2019 (COVID-19) pandemic has led to various complications, including cardiovascular events. Despite the widespread impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant in 2022, no studies have evaluated the relationship between the Omicron variant epidemic and acute myocardial infarction (AMI).
Methods: We utilized a Japanese claims database to identify patients diagnosed with COVID-19 between January 1, 2022, and December 31, 2022. We also identified patients who developed AMI within 90 days before and after their COVID-19 diagnosis. A self-controlled case series (SCCS) analysis evaluated the incidence rate ratio (IRR) for AMI.
Results: Of the 360,589 patients with COVID-19, 759 were diagnosed with AMI. Excluding the day of exposure, the SCCS analysis showed an IRR for AMI of 6.65 (95% confidence interval [CI]: 4.66-9.48, P<0.001) for the 1st week, 1.90 (95% CI: 1.05-3.50, P=0.03) for the 2nd week, and 0.95 (95% CI: 0.52-1.72, P=0.87) for the 3rd and 4th weeks following COVID-19. Including the day of exposure, the IRR was 77.4 (95% CI: 63.2-94.9, P<0.001) for the 1st week, 1.90 (95% CI: 1.05-3.50, P=0.03) for the 2nd week, and 0.95 (95% CI: 0.52-1.72, P=0.87) for the 3rd and 4th weeks following COVID-19.
Conclusions: This study showed that the SARS-CoV-2 Omicron variant epidemic increased AMI incidence. These findings highlight AMI as a COVID-19 characteristic, emphasize the importance of SARS-CoV-2 vaccination, and underline the need for continued vigilance, even with variant changes.
Keywords: COVID-19; acute myocardial infarction; epidemic; omicron variant.