tetano
Editor, Senior Moderator
J Infect Chemother
. 2020 Sep 30;S1341-321X(20)30350-0.
doi: 10.1016/j.jiac.2020.09.030. Online ahead of print.
Severe olfactory and gustatory dysfunctions in a Japanese pediatric patient with coronavirus disease (COVID-19)
Yuki Kasuga[SUP] 1 [/SUP], Koji Nishimura[SUP] 1 [/SUP], Hidetoshi Go[SUP] 1 [/SUP], Kimitaka Nakazaki[SUP] 1 [/SUP], Shoichi Shimizu[SUP] 1 [/SUP], Koji Kanezawa[SUP] 1 [/SUP], Makoto Tanaka[SUP] 2 [/SUP], Takeshi Oshima[SUP] 2 [/SUP], Ichiro Morioka[SUP] 3 [/SUP]
Affiliations
Abstract
Coronavirus disease (COVID-19) is often characterized by abnormal olfactory and gustatory symptoms in adults; however, detailed studies on pediatric patients with COVID-19 are extremely limited. A 13-year-old Japanese girl presented with fever and cough, and after 2 days, her olfactory and taste sensations suddenly disappeared. A real-time reverse transcriptase-polymerase chain reaction (RT-PCR) test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was performed using a nasopharyngeal swab. Because a positive result was seen, she was admitted on the 7th day of illness. On admission, the visual analogue scale (VAS) score for smell and taste was 0 of 100%. An intravenous olfaction test using prosultiamine (Alinamin test) was performed on the 15th day of illness to evaluate olfaction, and an increase in latency (33 seconds) and a decrease in duration (55 seconds) were observed. In the odor identification test using 12 different odor cards, only 7 odors were correctly identified. On the 18th day of illness, SARS-CoV-2 tested negative in the RT-PCR test; simultaneously, the VAS score for smell and taste fully improved to 100 of 100%. On the 77th day of illness, full recovery was confirmed in the Alinamin test (latency, 7 seconds; duration, 82 seconds). In this present case, an improvement in olfactory and gustatory dysfunctions was observed with negative results in RT-PCR test for SARS-CoV-2.
Keywords: Angiotensin-converting enzyme 2 receptor; Intravenous olfaction test; Real-time reverse transcriptase-polymerase chain reaction; Visual analogue scale.
. 2020 Sep 30;S1341-321X(20)30350-0.
doi: 10.1016/j.jiac.2020.09.030. Online ahead of print.
Severe olfactory and gustatory dysfunctions in a Japanese pediatric patient with coronavirus disease (COVID-19)
Yuki Kasuga[SUP] 1 [/SUP], Koji Nishimura[SUP] 1 [/SUP], Hidetoshi Go[SUP] 1 [/SUP], Kimitaka Nakazaki[SUP] 1 [/SUP], Shoichi Shimizu[SUP] 1 [/SUP], Koji Kanezawa[SUP] 1 [/SUP], Makoto Tanaka[SUP] 2 [/SUP], Takeshi Oshima[SUP] 2 [/SUP], Ichiro Morioka[SUP] 3 [/SUP]
Affiliations
- PMID: 33039267
- PMCID: PMC7526635
- DOI: 10.1016/j.jiac.2020.09.030
Abstract
Coronavirus disease (COVID-19) is often characterized by abnormal olfactory and gustatory symptoms in adults; however, detailed studies on pediatric patients with COVID-19 are extremely limited. A 13-year-old Japanese girl presented with fever and cough, and after 2 days, her olfactory and taste sensations suddenly disappeared. A real-time reverse transcriptase-polymerase chain reaction (RT-PCR) test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was performed using a nasopharyngeal swab. Because a positive result was seen, she was admitted on the 7th day of illness. On admission, the visual analogue scale (VAS) score for smell and taste was 0 of 100%. An intravenous olfaction test using prosultiamine (Alinamin test) was performed on the 15th day of illness to evaluate olfaction, and an increase in latency (33 seconds) and a decrease in duration (55 seconds) were observed. In the odor identification test using 12 different odor cards, only 7 odors were correctly identified. On the 18th day of illness, SARS-CoV-2 tested negative in the RT-PCR test; simultaneously, the VAS score for smell and taste fully improved to 100 of 100%. On the 77th day of illness, full recovery was confirmed in the Alinamin test (latency, 7 seconds; duration, 82 seconds). In this present case, an improvement in olfactory and gustatory dysfunctions was observed with negative results in RT-PCR test for SARS-CoV-2.
Keywords: Angiotensin-converting enzyme 2 receptor; Intravenous olfaction test; Real-time reverse transcriptase-polymerase chain reaction; Visual analogue scale.