tetano
Editor, Senior Moderator
J Infect Chemother
. 2021 Nov 10;S1341-321X(21)00299-3.
doi: 10.1016/j.jiac.2021.10.026. Online ahead of print.
Evaluation and clinical implications of the time to a positive results of antigen testing for SARS-CoV-2
Yusaku Akashi[SUP] 1 [/SUP], Yoshihiko Kiyasu[SUP] 2 [/SUP], Yuto Takeuchi[SUP] 3 [/SUP], Daisuke Kato[SUP] 4 [/SUP], Miwa Kuwahara[SUP] 5 [/SUP], Shino Muramatsu[SUP] 6 [/SUP], Atsuo Ueda[SUP] 7 [/SUP], Shigeyuki Notake[SUP] 8 [/SUP], Koji Nakamura[SUP] 9 [/SUP], Hiroichi Ishikawa[SUP] 10 [/SUP], Hiromichi Suzuki[SUP] 11 [/SUP]
Affiliations
Abstract
Introduction: Antigen tests for severe acute respiratory coronavirus 2 sometimes show positive lines earlier than their specified read time, although the implication of getting the results at earlier time is not well understood.
Methods: We prospectively collected additional nasopharyngeal samples from patients who had already tested positive for SARS-CoV-2 by reverse transcription PCR. The swab was used for an antigen test, QuickNavi™-COVID19 Ag, and the time periods to get positive results were measured.
Results: In 84 of 96 (87.5%) analyzed cases, the results of QuickNavi™-COVID19 Ag were positive. The time to obtain positive results was 15.0 seconds in median (inter quartile range: 12.0-33.3, range 11-736) and was extended in samples with higher cycle thresholds (p < 0.001). Positive lines appeared within a minute in 85.7% of cases and within 5 min in 96.4%.
Conclusion: QuickNavi™-COVID19 Ag immediately showed positive results in most cases, and the time to a positive reaction may have indicated the viral load.
Keywords: Antigen test; COVID-19; QuickNavi™-COVID19 Ag; SARS-CoV-2; Time to positive results.
. 2021 Nov 10;S1341-321X(21)00299-3.
doi: 10.1016/j.jiac.2021.10.026. Online ahead of print.
Evaluation and clinical implications of the time to a positive results of antigen testing for SARS-CoV-2
Yusaku Akashi[SUP] 1 [/SUP], Yoshihiko Kiyasu[SUP] 2 [/SUP], Yuto Takeuchi[SUP] 3 [/SUP], Daisuke Kato[SUP] 4 [/SUP], Miwa Kuwahara[SUP] 5 [/SUP], Shino Muramatsu[SUP] 6 [/SUP], Atsuo Ueda[SUP] 7 [/SUP], Shigeyuki Notake[SUP] 8 [/SUP], Koji Nakamura[SUP] 9 [/SUP], Hiroichi Ishikawa[SUP] 10 [/SUP], Hiromichi Suzuki[SUP] 11 [/SUP]
Affiliations
- PMID: 34799237
- DOI: 10.1016/j.jiac.2021.10.026
Abstract
Introduction: Antigen tests for severe acute respiratory coronavirus 2 sometimes show positive lines earlier than their specified read time, although the implication of getting the results at earlier time is not well understood.
Methods: We prospectively collected additional nasopharyngeal samples from patients who had already tested positive for SARS-CoV-2 by reverse transcription PCR. The swab was used for an antigen test, QuickNavi™-COVID19 Ag, and the time periods to get positive results were measured.
Results: In 84 of 96 (87.5%) analyzed cases, the results of QuickNavi™-COVID19 Ag were positive. The time to obtain positive results was 15.0 seconds in median (inter quartile range: 12.0-33.3, range 11-736) and was extended in samples with higher cycle thresholds (p < 0.001). Positive lines appeared within a minute in 85.7% of cases and within 5 min in 96.4%.
Conclusion: QuickNavi™-COVID19 Ag immediately showed positive results in most cases, and the time to a positive reaction may have indicated the viral load.
Keywords: Antigen test; COVID-19; QuickNavi™-COVID19 Ag; SARS-CoV-2; Time to positive results.