tetano
Editor, Senior Moderator
J Infect Chemother
. 2020 Sep 9;S1341-321X(20)30330-5.
doi: 10.1016/j.jiac.2020.09.010. Online ahead of print.
Could threshold cycle value correctly reflect the severity of novel coronavirus disease 2019 (COVID-19)?
Nobuhiro Asai[SUP] 1 [/SUP], Daisuke Sakanashi[SUP] 2 [/SUP], Wataru Ohashi[SUP] 3 [/SUP], Akiko Nakamura[SUP] 2 [/SUP], Atsuko Yamada[SUP] 2 [/SUP], Yuzuka Kawamoto[SUP] 2 [/SUP], Narimi Miyazaki[SUP] 2 [/SUP], Tomoko Ohno[SUP] 2 [/SUP], Isao Koita[SUP] 2 [/SUP], Hiroyuki Suematsu[SUP] 2 [/SUP], Takaaki Kishino[SUP] 4 [/SUP], Hideo Kato[SUP] 5 [/SUP], Mao Hagihara[SUP] 6 [/SUP], Arufumi Shiota[SUP] 1 [/SUP], Yusuke Koizumi[SUP] 1 [/SUP], Yuka Yamagishi[SUP] 1 [/SUP], Hiroshige Mikamo[SUP] 7 [/SUP]
Affiliations
Abstract
The novel coronavirus disease 2019 (COVID-19) is diagnosed by positive result of reverse transcription polymerase chain reaction (RT-PCR) for the novel coronavirus. We concluded that cycle threshold value (Ct-value) of real-time RT-PCR (rRT-PCR) assay could decrease as patients recover. Results of rRT-PCR assay could remain positive among asymptomatic patients for longer than 2 weeks. The discharge criteria of COVID-19 patients using a negative result of rRT-PCR should be reconsidered.
Keywords: COVID-19; Coronavirus; RT-PCR; SARS-CoV-2; Wuhan.
. 2020 Sep 9;S1341-321X(20)30330-5.
doi: 10.1016/j.jiac.2020.09.010. Online ahead of print.
Could threshold cycle value correctly reflect the severity of novel coronavirus disease 2019 (COVID-19)?
Nobuhiro Asai[SUP] 1 [/SUP], Daisuke Sakanashi[SUP] 2 [/SUP], Wataru Ohashi[SUP] 3 [/SUP], Akiko Nakamura[SUP] 2 [/SUP], Atsuko Yamada[SUP] 2 [/SUP], Yuzuka Kawamoto[SUP] 2 [/SUP], Narimi Miyazaki[SUP] 2 [/SUP], Tomoko Ohno[SUP] 2 [/SUP], Isao Koita[SUP] 2 [/SUP], Hiroyuki Suematsu[SUP] 2 [/SUP], Takaaki Kishino[SUP] 4 [/SUP], Hideo Kato[SUP] 5 [/SUP], Mao Hagihara[SUP] 6 [/SUP], Arufumi Shiota[SUP] 1 [/SUP], Yusuke Koizumi[SUP] 1 [/SUP], Yuka Yamagishi[SUP] 1 [/SUP], Hiroshige Mikamo[SUP] 7 [/SUP]
Affiliations
- PMID: 32994136
- DOI: 10.1016/j.jiac.2020.09.010
Abstract
The novel coronavirus disease 2019 (COVID-19) is diagnosed by positive result of reverse transcription polymerase chain reaction (RT-PCR) for the novel coronavirus. We concluded that cycle threshold value (Ct-value) of real-time RT-PCR (rRT-PCR) assay could decrease as patients recover. Results of rRT-PCR assay could remain positive among asymptomatic patients for longer than 2 weeks. The discharge criteria of COVID-19 patients using a negative result of rRT-PCR should be reconsidered.
Keywords: COVID-19; Coronavirus; RT-PCR; SARS-CoV-2; Wuhan.