tetano
Editor, Senior Moderator
J Infect Chemother
. 2020 Sep 6;S1341-321X(20)30323-8.
doi: 10.1016/j.jiac.2020.09.003. Online ahead of print.
Comparison of COVID-19 disease between young and elderly patients: Hidden viral shedding of COVID-19
Hitoshi Mori[SUP] 1 [/SUP], Hirofumi Obinata[SUP] 2 [/SUP], Wakana Murakami[SUP] 3 [/SUP], Kodama Tatsuya[SUP] 2 [/SUP], Hisashi Sasaki[SUP] 2 [/SUP], Yu Miyake[SUP] 2 [/SUP], Yasuaki Taniguchi[SUP] 2 [/SUP], Shinichiro Ota[SUP] 2 [/SUP], Mitsuki Yamaga[SUP] 2 [/SUP], Yohsuke Suyama[SUP] 4 [/SUP], Kaku Tamura[SUP] 2 [/SUP]
Affiliations
Abstract
Objectives: The symptoms of Coronavirus disease 2019 (COVID-19) vary among patients. The aim of this study was to investigate the clinical manifestation and disease duration in young versus elderly patients.
Methods: We retrospectively analyzed 187 patients (87 elderly and 100 young patients) with confirmed COVID-19. The clinical characteristics and chest computed tomography (CT) extent as defined by a score were compared between the two groups.
Results: The numbers of asymptomatic cases and severe cases were significantly higher in the elderly group (elderly group vs. young group; asymptomatic cases, 31 [35.6%] vs. 10 [10%], p < 0.0001; severe cases, 25 [28.7%] vs. 8 [8.0%], p = 0.0002). The proportion of asymptomatic patients and severe patients increased across the 10-year age groups. There was no significant difference in the total CT score and number of abnormal cases. A significant positive correlation between the disease duration and patient age was observed in asymptomatic patients (ρ = 0.4570, 95% CI 0.1198-0.6491, p = 0.0034).
Conclusions: Although the extent of lung involvement did not have a significant difference between the young and elderly patients, elderly patients were more likely to have severe clinical manifestations. Elderly patients were also more likely to be asymptomatic and a source of COVID-19 viral shedding.
Keywords: Asymptomatic patients; COVID-19; Clinical characteristics; Elderly patients; Young patients.
. 2020 Sep 6;S1341-321X(20)30323-8.
doi: 10.1016/j.jiac.2020.09.003. Online ahead of print.
Comparison of COVID-19 disease between young and elderly patients: Hidden viral shedding of COVID-19
Hitoshi Mori[SUP] 1 [/SUP], Hirofumi Obinata[SUP] 2 [/SUP], Wakana Murakami[SUP] 3 [/SUP], Kodama Tatsuya[SUP] 2 [/SUP], Hisashi Sasaki[SUP] 2 [/SUP], Yu Miyake[SUP] 2 [/SUP], Yasuaki Taniguchi[SUP] 2 [/SUP], Shinichiro Ota[SUP] 2 [/SUP], Mitsuki Yamaga[SUP] 2 [/SUP], Yohsuke Suyama[SUP] 4 [/SUP], Kaku Tamura[SUP] 2 [/SUP]
Affiliations
- PMID: 32950393
- DOI: 10.1016/j.jiac.2020.09.003
Abstract
Objectives: The symptoms of Coronavirus disease 2019 (COVID-19) vary among patients. The aim of this study was to investigate the clinical manifestation and disease duration in young versus elderly patients.
Methods: We retrospectively analyzed 187 patients (87 elderly and 100 young patients) with confirmed COVID-19. The clinical characteristics and chest computed tomography (CT) extent as defined by a score were compared between the two groups.
Results: The numbers of asymptomatic cases and severe cases were significantly higher in the elderly group (elderly group vs. young group; asymptomatic cases, 31 [35.6%] vs. 10 [10%], p < 0.0001; severe cases, 25 [28.7%] vs. 8 [8.0%], p = 0.0002). The proportion of asymptomatic patients and severe patients increased across the 10-year age groups. There was no significant difference in the total CT score and number of abnormal cases. A significant positive correlation between the disease duration and patient age was observed in asymptomatic patients (ρ = 0.4570, 95% CI 0.1198-0.6491, p = 0.0034).
Conclusions: Although the extent of lung involvement did not have a significant difference between the young and elderly patients, elderly patients were more likely to have severe clinical manifestations. Elderly patients were also more likely to be asymptomatic and a source of COVID-19 viral shedding.
Keywords: Asymptomatic patients; COVID-19; Clinical characteristics; Elderly patients; Young patients.