tetano
Editor, Senior Moderator
J Infect Chemother
. 2020 Nov 12;S1341-321X(20)30380-9.
doi: 10.1016/j.jiac.2020.10.021. Online ahead of print.
Clinical manifestations of adult patients requiring influenza-associated hospitalization: A prospective multicenter cohort study in Japan via internet surveillance
Tadashi Ishida[SUP] 1 [/SUP], Masafumi Seki[SUP] 2 [/SUP], Kazunori Oishi[SUP] 3 [/SUP], Kazuhiro Tateda[SUP] 4 [/SUP], Jiro Fujita[SUP] 5 [/SUP], Jun-Ichi Kadota[SUP] 6 [/SUP], Akihiko Kawana[SUP] 7 [/SUP], Koichi Izumikawa[SUP] 8 [/SUP], Toshiaki Kikuchi[SUP] 9 [/SUP], Norio Ohmagari[SUP] 10 [/SUP], Mitsuhiro Yamada[SUP] 11 [/SUP], Takaya Maruyama[SUP] 12 [/SUP], Takahiro Takazono[SUP] 8 [/SUP], Makoto Miki[SUP] 13 [/SUP], Yoshitsugu Miyazaki[SUP] 14 [/SUP], Yoshitaka Yamazaki[SUP] 15 [/SUP], Hiroshi Kakeya[SUP] 16 [/SUP], Kenji Ogawa[SUP] 17 [/SUP], Hideaki Nagai[SUP] 18 [/SUP], Akira Watanabe[SUP] 19 [/SUP]
Affiliations
Abstract
Introduction: Influenza remains a clinically heavy burden worldwide. The objective of this study was to clarify clinical manifestations of severely ill patients infected with influenza.
Methods: The clinical data for patients who were severely ill with influenza, and required hospitalization were gathered and analyzed between November 2014 and August 2019 (5 influenza seasons) using an internet-surveillance system.
Results: A total of 924 patients were enrolled and analyzed. The median age was 78 years (IQR, 67-84), and the patients in the 2015-2016 season were significantly younger than those in other seasons. Pneumonia was the most common disease indicated as a cause for hospitalization, followed by a poor general condition and exacerbation of underlying respiratory diseases. Antiviral drugs were administered in 97.0% of the patients with peramivir being the most-frequently use antiviral. In-hospital death was recorded for 44 patients (4.8%). Multivariate analysis indicated that nursing home resident (OR: 6.554) and obesity (OR: 24.343) were independent predictors of in-hospital mortality.
Conclusions: Complications of influenza infection remain a heavy burden especially among the elderly. Continuous nationwide surveillance will be required to grasp the actual situation of influenza epidemics. (UMIN000015989).
Keywords: Elderly; Hospitalization; Influenza; Internet-surveillance system; Mortality.
. 2020 Nov 12;S1341-321X(20)30380-9.
doi: 10.1016/j.jiac.2020.10.021. Online ahead of print.
Clinical manifestations of adult patients requiring influenza-associated hospitalization: A prospective multicenter cohort study in Japan via internet surveillance
Tadashi Ishida[SUP] 1 [/SUP], Masafumi Seki[SUP] 2 [/SUP], Kazunori Oishi[SUP] 3 [/SUP], Kazuhiro Tateda[SUP] 4 [/SUP], Jiro Fujita[SUP] 5 [/SUP], Jun-Ichi Kadota[SUP] 6 [/SUP], Akihiko Kawana[SUP] 7 [/SUP], Koichi Izumikawa[SUP] 8 [/SUP], Toshiaki Kikuchi[SUP] 9 [/SUP], Norio Ohmagari[SUP] 10 [/SUP], Mitsuhiro Yamada[SUP] 11 [/SUP], Takaya Maruyama[SUP] 12 [/SUP], Takahiro Takazono[SUP] 8 [/SUP], Makoto Miki[SUP] 13 [/SUP], Yoshitsugu Miyazaki[SUP] 14 [/SUP], Yoshitaka Yamazaki[SUP] 15 [/SUP], Hiroshi Kakeya[SUP] 16 [/SUP], Kenji Ogawa[SUP] 17 [/SUP], Hideaki Nagai[SUP] 18 [/SUP], Akira Watanabe[SUP] 19 [/SUP]
Affiliations
- PMID: 33189538
- DOI: 10.1016/j.jiac.2020.10.021
Abstract
Introduction: Influenza remains a clinically heavy burden worldwide. The objective of this study was to clarify clinical manifestations of severely ill patients infected with influenza.
Methods: The clinical data for patients who were severely ill with influenza, and required hospitalization were gathered and analyzed between November 2014 and August 2019 (5 influenza seasons) using an internet-surveillance system.
Results: A total of 924 patients were enrolled and analyzed. The median age was 78 years (IQR, 67-84), and the patients in the 2015-2016 season were significantly younger than those in other seasons. Pneumonia was the most common disease indicated as a cause for hospitalization, followed by a poor general condition and exacerbation of underlying respiratory diseases. Antiviral drugs were administered in 97.0% of the patients with peramivir being the most-frequently use antiviral. In-hospital death was recorded for 44 patients (4.8%). Multivariate analysis indicated that nursing home resident (OR: 6.554) and obesity (OR: 24.343) were independent predictors of in-hospital mortality.
Conclusions: Complications of influenza infection remain a heavy burden especially among the elderly. Continuous nationwide surveillance will be required to grasp the actual situation of influenza epidemics. (UMIN000015989).
Keywords: Elderly; Hospitalization; Influenza; Internet-surveillance system; Mortality.