tetano
Editor, Senior Moderator
J Infect Chemother
. 2023 Apr 13;S1341-321X(23)00088-0.
doi: 10.1016/j.jiac.2023.04.003. Online ahead of print.
Acute cerebellar ataxia during acute COVID-19: A case series and review of the literature
Hiroyuki Takao[SUP] 1 [/SUP], Hiroyuki Iijima[SUP] 2 [/SUP], Rika Odagiri[SUP] 1 [/SUP], Itaru Hayakawa[SUP] 3 [/SUP], Chikara Ogimi[SUP] 4 [/SUP]
Affiliations
Abstract
Acute coronavirus disease 2019 (COVID-19)-associated cerebellar ataxia without multisystem inflammatory syndrome in children (MIS-C) or encephalopathy in children has been rarely reported. We reviewed medical records of hospitalized children who had developed cerebellar ataxia during the acute phase of COVID-19 infection, without MIS-C or encephalopathy, in our center. We also conducted a literature review and summarized the clinical characteristics, treatment, and outcomes. We found three cases in our center and additional three cases in the literature. All patients were male and five were preschool children. The cerebellar symptoms started between day 2 and day 10 during the acute phase of the COVID-19 infection. Two cases were complicated by mutism. One patient received therapy for acute cerebellar ataxia with corticosteroids, and others did not receive any specific therapy for acute cerebellar ataxia. The symptoms improved completely in all patients, with the recovery interval ranging from one week to two months. Further studies are warranted to elucidate the pathogenesis of acute cerebellar ataxia during acute COVID-19 in children.
Keywords: Acute ataxia; Children; Coronavirus disease 2019; Omicron variant of concern; Seizures.
. 2023 Apr 13;S1341-321X(23)00088-0.
doi: 10.1016/j.jiac.2023.04.003. Online ahead of print.
Acute cerebellar ataxia during acute COVID-19: A case series and review of the literature
Hiroyuki Takao[SUP] 1 [/SUP], Hiroyuki Iijima[SUP] 2 [/SUP], Rika Odagiri[SUP] 1 [/SUP], Itaru Hayakawa[SUP] 3 [/SUP], Chikara Ogimi[SUP] 4 [/SUP]
Affiliations
- PMID: 37061090
- PMCID: PMC10101482
- DOI: 10.1016/j.jiac.2023.04.003
Abstract
Acute coronavirus disease 2019 (COVID-19)-associated cerebellar ataxia without multisystem inflammatory syndrome in children (MIS-C) or encephalopathy in children has been rarely reported. We reviewed medical records of hospitalized children who had developed cerebellar ataxia during the acute phase of COVID-19 infection, without MIS-C or encephalopathy, in our center. We also conducted a literature review and summarized the clinical characteristics, treatment, and outcomes. We found three cases in our center and additional three cases in the literature. All patients were male and five were preschool children. The cerebellar symptoms started between day 2 and day 10 during the acute phase of the COVID-19 infection. Two cases were complicated by mutism. One patient received therapy for acute cerebellar ataxia with corticosteroids, and others did not receive any specific therapy for acute cerebellar ataxia. The symptoms improved completely in all patients, with the recovery interval ranging from one week to two months. Further studies are warranted to elucidate the pathogenesis of acute cerebellar ataxia during acute COVID-19 in children.
Keywords: Acute ataxia; Children; Coronavirus disease 2019; Omicron variant of concern; Seizures.