tetano
Editor, Senior Moderator
J Infect Chemother
. 2021 Apr 1;S1341-321X(21)00105-7.
doi: 10.1016/j.jiac.2021.03.024. Online ahead of print.
A fatal case of COVID-19-associated invasive pulmonary aspergillosis
Yuto Iwanaga[SUP] 1 [/SUP], Toshinori Kawanami[SUP] 1 [/SUP], Kei Yamasaki[SUP] 2 [/SUP], Hideki Sakakibara[SUP] 1 [/SUP], Issei Ikushima[SUP] 1 [/SUP], Hiroaki Ikegami[SUP] 1 [/SUP], Masahiro Tahara[SUP] 1 [/SUP], Kentaro Akata[SUP] 1 [/SUP], Hiroshi Mukae[SUP] 3 [/SUP], Kazuhiro Yatera[SUP] 1 [/SUP]
Affiliations
Abstract
A 79-year-old Japanese man with polymyalgia rheumatica was admitted to hospital with coronavirus disease (COVID-19). On admission, he was treated with ciclesonide inhalation, ivermectin, and meropenem. He was intubated 6 days after admission, and methylprednisolone therapy was initiated (1000 mg/day). Hypoxemia and chest radiographic findings temporarily improved. However, chest computed tomography showed bilateral ground-glass attenuations, multiple nodules, and consolidation. Aspergillus fumigatus was cultured from the tracheal aspirate and he was diagnosed with COVID-19-associated invasive pulmonary aspergillosis (CAPA) and treated with liposomal amphotericin B. However, he died 28 days after admission.
Keywords: Acute respiratory distress syndrome; COVID-19; COVID-19 associated invasive pulmonary aspergillosis.
. 2021 Apr 1;S1341-321X(21)00105-7.
doi: 10.1016/j.jiac.2021.03.024. Online ahead of print.
A fatal case of COVID-19-associated invasive pulmonary aspergillosis
Yuto Iwanaga[SUP] 1 [/SUP], Toshinori Kawanami[SUP] 1 [/SUP], Kei Yamasaki[SUP] 2 [/SUP], Hideki Sakakibara[SUP] 1 [/SUP], Issei Ikushima[SUP] 1 [/SUP], Hiroaki Ikegami[SUP] 1 [/SUP], Masahiro Tahara[SUP] 1 [/SUP], Kentaro Akata[SUP] 1 [/SUP], Hiroshi Mukae[SUP] 3 [/SUP], Kazuhiro Yatera[SUP] 1 [/SUP]
Affiliations
- PMID: 33867266
- DOI: 10.1016/j.jiac.2021.03.024
Abstract
A 79-year-old Japanese man with polymyalgia rheumatica was admitted to hospital with coronavirus disease (COVID-19). On admission, he was treated with ciclesonide inhalation, ivermectin, and meropenem. He was intubated 6 days after admission, and methylprednisolone therapy was initiated (1000 mg/day). Hypoxemia and chest radiographic findings temporarily improved. However, chest computed tomography showed bilateral ground-glass attenuations, multiple nodules, and consolidation. Aspergillus fumigatus was cultured from the tracheal aspirate and he was diagnosed with COVID-19-associated invasive pulmonary aspergillosis (CAPA) and treated with liposomal amphotericin B. However, he died 28 days after admission.
Keywords: Acute respiratory distress syndrome; COVID-19; COVID-19 associated invasive pulmonary aspergillosis.