tetano
Editor, Senior Moderator
J Infect
. 2020 Jul 4;S0163-4453(20)30460-6.
doi: 10.1016/j.jinf.2020.07.002. Online ahead of print.
A Comparison of Mortality-related Risk Factors of COVID-19, SARS, and MERS: A Systematic Review and Meta-analysis
Lvliang Lu[SUP] 1 [/SUP], Wenyu Zhong[SUP] 1 [/SUP], Ziwei Bian[SUP] 1 [/SUP], Zhiming Li[SUP] 1 [/SUP], Ke Zhang[SUP] 1 [/SUP], Boxuan Liang[SUP] 1 [/SUP], Yizhou Zhong[SUP] 1 [/SUP], Manjiang Hu[SUP] 1 [/SUP], Li Lin[SUP] 1 [/SUP], Jun Liu[SUP] 1 [/SUP], Xi Lin[SUP] 1 [/SUP], Yuji Huang[SUP] 1 [/SUP], Junying Jiang[SUP] 2 [/SUP], Xingfen Yang[SUP] 3 [/SUP], Xin Zhang[SUP] 4 [/SUP], Zhenlie Huang[SUP] 5 [/SUP]
Affiliations
Abstract
Objective: Coronavirus Disease 2019 (COVID-19) is a pandemic. This systematic review compares mortality risk factors including clinical, demographic and laboratory features of COVID-19, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). The aim is to provide new strategies for COVID-19 prevention and treatment.
Methods: We performed a systematic review with meta-analysis, using five databases to compare the predictors of death for COVID-19, SARS and MERS. A random-effects model meta-analysis calculated odds ratios (OR) and 95% confidence intervals (95% CI).
Results: 845 articles up through 11/4/2020 were retrieved, but only 28 studies were included in this meta-analysis. The results showed that males had a higher likelihood of death than females (OR = 1.82, 95% CI 1.56-2.13). Age (OR = 7.86, 95% CI 5.46-11.29), diabetes comorbidity (OR = 3.73, 95% CI 2.35-5.90), chronic lung disease (OR = 3.43, 95% CI 1.80-6.52) and hypertension (OR = 3.38, 95% CI 2.45-4.67) were the mortality risk factors. The laboratory indicators lactic dehydrogenase (OR = 37.52, 95% CI 24.68-57.03), C-reactive protein (OR = 12.11, 95% CI 5.24-27.98), and neutrophils (OR = 17.56, 95% CI 10.67-28.90) had stronger correlations with COVID-19 mortality than with SARS or MERS mortality. Consolidation and ground-glass opacity imaging features were similar among COVID-19, SARS, and MERS patients.
Conclusions: COVID-19's mortality factors are similar to those of SARS and MERS. Age and laboratory indicators could be effective predictors of COVID-19 mortality outcomes.
Keywords: COVID-19; MERS; Meta-analysis; Mortality; Risk factors; SARS.
. 2020 Jul 4;S0163-4453(20)30460-6.
doi: 10.1016/j.jinf.2020.07.002. Online ahead of print.
A Comparison of Mortality-related Risk Factors of COVID-19, SARS, and MERS: A Systematic Review and Meta-analysis
Lvliang Lu[SUP] 1 [/SUP], Wenyu Zhong[SUP] 1 [/SUP], Ziwei Bian[SUP] 1 [/SUP], Zhiming Li[SUP] 1 [/SUP], Ke Zhang[SUP] 1 [/SUP], Boxuan Liang[SUP] 1 [/SUP], Yizhou Zhong[SUP] 1 [/SUP], Manjiang Hu[SUP] 1 [/SUP], Li Lin[SUP] 1 [/SUP], Jun Liu[SUP] 1 [/SUP], Xi Lin[SUP] 1 [/SUP], Yuji Huang[SUP] 1 [/SUP], Junying Jiang[SUP] 2 [/SUP], Xingfen Yang[SUP] 3 [/SUP], Xin Zhang[SUP] 4 [/SUP], Zhenlie Huang[SUP] 5 [/SUP]
Affiliations
- PMID: 32634459
- DOI: 10.1016/j.jinf.2020.07.002
Abstract
Objective: Coronavirus Disease 2019 (COVID-19) is a pandemic. This systematic review compares mortality risk factors including clinical, demographic and laboratory features of COVID-19, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). The aim is to provide new strategies for COVID-19 prevention and treatment.
Methods: We performed a systematic review with meta-analysis, using five databases to compare the predictors of death for COVID-19, SARS and MERS. A random-effects model meta-analysis calculated odds ratios (OR) and 95% confidence intervals (95% CI).
Results: 845 articles up through 11/4/2020 were retrieved, but only 28 studies were included in this meta-analysis. The results showed that males had a higher likelihood of death than females (OR = 1.82, 95% CI 1.56-2.13). Age (OR = 7.86, 95% CI 5.46-11.29), diabetes comorbidity (OR = 3.73, 95% CI 2.35-5.90), chronic lung disease (OR = 3.43, 95% CI 1.80-6.52) and hypertension (OR = 3.38, 95% CI 2.45-4.67) were the mortality risk factors. The laboratory indicators lactic dehydrogenase (OR = 37.52, 95% CI 24.68-57.03), C-reactive protein (OR = 12.11, 95% CI 5.24-27.98), and neutrophils (OR = 17.56, 95% CI 10.67-28.90) had stronger correlations with COVID-19 mortality than with SARS or MERS mortality. Consolidation and ground-glass opacity imaging features were similar among COVID-19, SARS, and MERS patients.
Conclusions: COVID-19's mortality factors are similar to those of SARS and MERS. Age and laboratory indicators could be effective predictors of COVID-19 mortality outcomes.
Keywords: COVID-19; MERS; Meta-analysis; Mortality; Risk factors; SARS.