tetano
Editor, Senior Moderator
J Infect. 2020 Apr 20. pii: S0163-4453(20)30207-3. doi: 10.1016/j.jinf.2020.04.001. [Epub ahead of print]
The profile of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus pneumonia.
Li H[SUP]1[/SUP], Chen K[SUP]1[/SUP], Liu M[SUP]2[/SUP], Xu H[SUP]2[/SUP], Xu Q[SUP]3[/SUP].
Author information
Abstract
OBJECTIVES:
The study was aimed at investigating the characteristics of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus (2019-nCoV) pneumonia.
METHODS:
Children with 2019-nCoV pneumonia or with respiratory syncytial virus (RSV) pneumonia were included. Data including lymphocyte subsets and serum cytokines were collected and analyzed.
RESULTS:
56 patients were included in the study, 40 children with 2019-nCoV pneumonia and 16 children with RSV pneumonia. Compared with children with RSV pneumonia, patients with 2019-nCoV pneumonia had higher count of CD3+8+ lymphocyte, higher percentages of CD3+, CD3+8+ lymphocytes and a lower percentage of CD19+ lymphocyte. The serum IL-10 level was significantly higher in children with RSV pneumonia. One 2019-nCoV pneumonia child who was with an obvious increase of IL-10 developed severe pneumonia.
CONCLUSIONS:
Immune response played a very important role in the development of 2019-nCoV pneumonia. The effective CD8+ T cell response might influence the severity of 2019-nCoV pneumonia. The adaptable change in IL-10 level might contribute to the relatively mild pneumonia symptoms in children with 2019-nCoV pneumonia and bacterial co-infection might be a risk factor of severe 2019-nCoV pneumonia.
Copyright ? 2020. Published by Elsevier Ltd.
KEYWORDS:
2019 novel coronavirus pneumonia; Children; Lymphocyte subsets; Serum cytokines
PMID:32325129DOI:10.1016/j.jinf.2020.04.001
The profile of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus pneumonia.
Li H[SUP]1[/SUP], Chen K[SUP]1[/SUP], Liu M[SUP]2[/SUP], Xu H[SUP]2[/SUP], Xu Q[SUP]3[/SUP].
Author information
Abstract
OBJECTIVES:
The study was aimed at investigating the characteristics of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus (2019-nCoV) pneumonia.
METHODS:
Children with 2019-nCoV pneumonia or with respiratory syncytial virus (RSV) pneumonia were included. Data including lymphocyte subsets and serum cytokines were collected and analyzed.
RESULTS:
56 patients were included in the study, 40 children with 2019-nCoV pneumonia and 16 children with RSV pneumonia. Compared with children with RSV pneumonia, patients with 2019-nCoV pneumonia had higher count of CD3+8+ lymphocyte, higher percentages of CD3+, CD3+8+ lymphocytes and a lower percentage of CD19+ lymphocyte. The serum IL-10 level was significantly higher in children with RSV pneumonia. One 2019-nCoV pneumonia child who was with an obvious increase of IL-10 developed severe pneumonia.
CONCLUSIONS:
Immune response played a very important role in the development of 2019-nCoV pneumonia. The effective CD8+ T cell response might influence the severity of 2019-nCoV pneumonia. The adaptable change in IL-10 level might contribute to the relatively mild pneumonia symptoms in children with 2019-nCoV pneumonia and bacterial co-infection might be a risk factor of severe 2019-nCoV pneumonia.
Copyright ? 2020. Published by Elsevier Ltd.
KEYWORDS:
2019 novel coronavirus pneumonia; Children; Lymphocyte subsets; Serum cytokines
PMID:32325129DOI:10.1016/j.jinf.2020.04.001