Giuseppe
Emeritus
To see the abstract of the paper (and links for free full texts PDF), please visit the thread http://www.flutrackers.com/forum/showpost.php?p=175151
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J Inf Dis: Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness, link t
- Thread starter Giuseppe
- Start date
Re: J Inf Dis: Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness, link to the abstract
Clin Microbiol Rev. 2006 Jul;19(3):571-82.Related Articles, <script language="JavaScript1.2"><!-- var Menu16847087 = [ ["UseLocalConfig", "jsmenu3Config", "", ""], ["Cited Articles" , "window.top.location='/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed_refs&LinkReadableName=Cited%20Articles&IdsFromResult=16847087&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract' ", "", ""], ["Free in PMC" , "window.top.location='http://www.pubmedcentral.gov/articlerender.fcgi?tool=pubmed&pubmedid=16847087&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract&ordinalpos=1' ", "", ""], ["Cited in PMC" , "window.top.location='http://www.pubmedcentral.gov/tocrender.fcgi?action=cited&tool=pubmed&pubmedid=16847087&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract&ordinalpos=1' ", "", ""], ["LinkOut", "window.top.location='/sites/entrez?Cmd=ShowLinkOut&Db=pubmed&TermToSearch=16847087&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract' ", "", ""] ] --></script>Links
[SIZE=+1]Insights into the interaction between influenza virus and pneumococcus.[/SIZE]
McCullers JA.
Department of Infectious Diseases, St. Jude Children's Research Hospital, 332 N. Lauderdale St., Memphis, TN 38105-2794, USA. jon.mccullers@stjude.org
Bacterial infections following influenza are an important cause of morbidity and mortality worldwide. Based on the historical importance of pneumonia as a cause of death during pandemic influenza, the increasingly likely possibility that highly pathogenic avian influenza viruses will trigger the next worldwide pandemic underscores the need to understand the multiple mechanisms underlying the interaction between influenza virus and bacterial pathogens such as Streptococcus pneumoniae. There is ample evidence to support the historical view that influenza virus alters the lungs in a way that predisposes to adherence, invasion, and induction of disease by pneumococcus. Access to receptors is a key factor and may be facilitated by the virus through epithelial damage, by exposure or up-regulation of receptors, or by provoking the epithelial regeneration response to cytotoxic damage. More recent data indicate that alteration of the immune response by diminishing the ability of the host to clear pneumococcus or by amplification of the inflammatory cascade is another key factor. Identification and exploration of the underlying mechanisms responsible for this synergism will provide targets for prevention and treatment using drugs and vaccines.
Clin Microbiol Rev. 2006 Jul;19(3):571-82.Related Articles, <script language="JavaScript1.2"><!-- var Menu16847087 = [ ["UseLocalConfig", "jsmenu3Config", "", ""], ["Cited Articles" , "window.top.location='/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed_refs&LinkReadableName=Cited%20Articles&IdsFromResult=16847087&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract' ", "", ""], ["Free in PMC" , "window.top.location='http://www.pubmedcentral.gov/articlerender.fcgi?tool=pubmed&pubmedid=16847087&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract&ordinalpos=1' ", "", ""], ["Cited in PMC" , "window.top.location='http://www.pubmedcentral.gov/tocrender.fcgi?action=cited&tool=pubmed&pubmedid=16847087&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract&ordinalpos=1' ", "", ""], ["LinkOut", "window.top.location='/sites/entrez?Cmd=ShowLinkOut&Db=pubmed&TermToSearch=16847087&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract' ", "", ""] ] --></script>Links
[SIZE=+1]Insights into the interaction between influenza virus and pneumococcus.[/SIZE]
McCullers JA.
Department of Infectious Diseases, St. Jude Children's Research Hospital, 332 N. Lauderdale St., Memphis, TN 38105-2794, USA. jon.mccullers@stjude.org
Bacterial infections following influenza are an important cause of morbidity and mortality worldwide. Based on the historical importance of pneumonia as a cause of death during pandemic influenza, the increasingly likely possibility that highly pathogenic avian influenza viruses will trigger the next worldwide pandemic underscores the need to understand the multiple mechanisms underlying the interaction between influenza virus and bacterial pathogens such as Streptococcus pneumoniae. There is ample evidence to support the historical view that influenza virus alters the lungs in a way that predisposes to adherence, invasion, and induction of disease by pneumococcus. Access to receptors is a key factor and may be facilitated by the virus through epithelial damage, by exposure or up-regulation of receptors, or by provoking the epithelial regeneration response to cytotoxic damage. More recent data indicate that alteration of the immune response by diminishing the ability of the host to clear pneumococcus or by amplification of the inflammatory cascade is another key factor. Identification and exploration of the underlying mechanisms responsible for this synergism will provide targets for prevention and treatment using drugs and vaccines.
gsgs
Registered User
Re: J Inf Dis: Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness, link to the abstract
yes, but do I have to read the whole paper to figure
out whether they are just formulating the problem
or whether there are also contributions to resolve it ?
yes, but do I have to read the whole paper to figure
out whether they are just formulating the problem
or whether there are also contributions to resolve it ?
Re: J Inf Dis: Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness, link to the abstract
It is therefore imperative that we have a firm understanding of the molecular basis of the interaction between influenza and the epidemiologically important bacteria that follow it?S. pneumoniae and S. aureus. Effective vaccination and timely use of the NA inhibitor class of drugs will likely have an impact on the incidence and severity of secondary bacterial complications during a pandemic. However, the availability of the drugs in this class is limited, and ongoing hurdles to developing an effective vaccine exist. Targeting viral or bacterial virulence factors that participate in the interaction between these organisms by using novel vaccine or anti-infective approaches should be a priority for the scientific and pharmaceutical communities.
It is therefore imperative that we have a firm understanding of the molecular basis of the interaction between influenza and the epidemiologically important bacteria that follow it?S. pneumoniae and S. aureus. Effective vaccination and timely use of the NA inhibitor class of drugs will likely have an impact on the incidence and severity of secondary bacterial complications during a pandemic. However, the availability of the drugs in this class is limited, and ongoing hurdles to developing an effective vaccine exist. Targeting viral or bacterial virulence factors that participate in the interaction between these organisms by using novel vaccine or anti-infective approaches should be a priority for the scientific and pharmaceutical communities.