Giuseppe
Emeritus
(1.4): J Immunol. 2008 Oct 15;181(8):5551-9.
Dynamics of human respiratory virus-specific CD8+ T cell responses in blood and airways during episodes of common cold.
Heidema J, Rossen JW, Lukens MV, Ketel MS, Scheltens E, Kranendonk ME, van Maren WW, van Loon AM, Otten HG, Kimpen JL, van Bleek GM. - Division of Paediatrics, Wilhelmina Children's Hospital, Utrecht, The Netherlands.
We determined the dynamics of CD8(+) T cells specific for influenza virus and respiratory syncytial virus in blood and tracheostoma aspirates of children during the course of respiratory infections.
We showed that during localized respiratory infections the ratio of activated effector CD8(+) T cells to resting memory/naive CD8(+) T cells in peripheral blood increased significantly.
Furthermore, the number of effector/memory T cells specific for respiratory viruses declined in blood and increased in the airways, suggesting that these T cells redistributed from blood to airways.
T cells specific for the infecting virus were present in the airways for longer periods at increased levels than nonspecifically recruited bystander T cells.
After clearance of the infection, the ratio of resting memory and naive CD8(+) T cells normalized in peripheral blood and also memory T cell numbers specific for unrelated viruses that declined during the infection due to bystander recruitment were restored.
Taken together, these results showed a significant systemic T cell response during relatively mild secondary infections and extensive dynamics of virus-specific and nonspecific Ag-experienced T cells.
PMID: 18832713 [PubMed - indexed for MEDLINE]
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Dynamics of human respiratory virus-specific CD8+ T cell responses in blood and airways during episodes of common cold.
Heidema J, Rossen JW, Lukens MV, Ketel MS, Scheltens E, Kranendonk ME, van Maren WW, van Loon AM, Otten HG, Kimpen JL, van Bleek GM. - Division of Paediatrics, Wilhelmina Children's Hospital, Utrecht, The Netherlands.
We determined the dynamics of CD8(+) T cells specific for influenza virus and respiratory syncytial virus in blood and tracheostoma aspirates of children during the course of respiratory infections.
We showed that during localized respiratory infections the ratio of activated effector CD8(+) T cells to resting memory/naive CD8(+) T cells in peripheral blood increased significantly.
Furthermore, the number of effector/memory T cells specific for respiratory viruses declined in blood and increased in the airways, suggesting that these T cells redistributed from blood to airways.
T cells specific for the infecting virus were present in the airways for longer periods at increased levels than nonspecifically recruited bystander T cells.
After clearance of the infection, the ratio of resting memory and naive CD8(+) T cells normalized in peripheral blood and also memory T cell numbers specific for unrelated viruses that declined during the infection due to bystander recruitment were restored.
Taken together, these results showed a significant systemic T cell response during relatively mild secondary infections and extensive dynamics of virus-specific and nonspecific Ag-experienced T cells.
PMID: 18832713 [PubMed - indexed for MEDLINE]
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