Giuseppe
Emeritus
J Immunol. 2009 Jan 1;182(1):29-33.
Cutting Edge: Antigen Presentation to CD8 T Cells after Influenza A Virus Infection.
Ingulli E, Funatake C, Jacovetty EL, Zanetti M. - Department of Pediatrics and.
Influenza A virus infection induces massive inflammation and lung damage.
Activation of CD8 T cells by dendritic cells (DCs) is necessary to control disease.
We undertook studies to track directly Ag presentation to CD8 T cells in vivo through the first 72 h after infection with OVA-expressing influenza A virus.
We found that Ag presentation by DCs occurs strictly in the draining lymph nodes and not within the lung itself.
Surprisingly, Ag presentation was found to be mediated by a CD11b(+) DC population.
Finally, the expression of antigenic complexes on DCs correlated with the location and timing of CD8 T cell activation.
These results have implications for approaches to control influenza A virus infection.
PMID: 19109130 [PubMed - as supplied by publisher]
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Cutting Edge: Antigen Presentation to CD8 T Cells after Influenza A Virus Infection.
Ingulli E, Funatake C, Jacovetty EL, Zanetti M. - Department of Pediatrics and.
Influenza A virus infection induces massive inflammation and lung damage.
Activation of CD8 T cells by dendritic cells (DCs) is necessary to control disease.
We undertook studies to track directly Ag presentation to CD8 T cells in vivo through the first 72 h after infection with OVA-expressing influenza A virus.
We found that Ag presentation by DCs occurs strictly in the draining lymph nodes and not within the lung itself.
Surprisingly, Ag presentation was found to be mediated by a CD11b(+) DC population.
Finally, the expression of antigenic complexes on DCs correlated with the location and timing of CD8 T cell activation.
These results have implications for approaches to control influenza A virus infection.
PMID: 19109130 [PubMed - as supplied by publisher]
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