tetano
Editor, Senior Moderator
J Hypertens
. 2022 Jun 1;40(Suppl 1):e169.
doi: 10.1097/01.hjh.0000837084.91831.2a.
COVID-19 IS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION: A META-ANALYSIS OF OBSERVATIONAL STUDIES
Dimitrios Patoulias[SUP] 1 [/SUP], Alexandra Katsimardou, Konstantinos Stavropoulos, Konstantinos Imprialos, Asterios Aidinis, Asimina Sviggou, Vasilios Kordalis, Athina Pyrpasopoulou, Christodoulos Papadopoulos, Michael Doumas
Affiliations
Abstract
Objective: A number of studies have indicated a deleterious effect of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection on endothelial function of enrolled subjects, further impairing during post-infectious stage. Endothelial function might indeed have a prognostic role in coronavirus disease-19 (COVID-19). Herein we sought to determine the effect of SARS-CoV-2 on endothelial function as quantified by flow-mediated dilation (FMD).
Design and method: We searched the PubMed database from inception till 21st December, 2021, for observational studies assessing the impact of SARS-CoV-2 on endothelial function either in the in-hospital or the outpatient setting. We set as primary efficacy outcome the mean difference in FMD between infected patients and healthy controls.
Results: We pooled data from 5 observational studies in a total of 541 enrolled subjects. One study enrolled children, while the rest 4 enrolled adults. Overall, COVID-19 induced a significant decrease in FMD by 3.29% (95% CI; -4.57 to -2.01, I2 = 81%) compared to healthy controls.
Conclusions: Despite being preliminary, these results suggest a significant effect of SARS-CoV-2 on endothelial system, leading to significant endothelial dysfunction. Prognostic implications of that effect have to be determined in prospective studies.
. 2022 Jun 1;40(Suppl 1):e169.
doi: 10.1097/01.hjh.0000837084.91831.2a.
COVID-19 IS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION: A META-ANALYSIS OF OBSERVATIONAL STUDIES
Dimitrios Patoulias[SUP] 1 [/SUP], Alexandra Katsimardou, Konstantinos Stavropoulos, Konstantinos Imprialos, Asterios Aidinis, Asimina Sviggou, Vasilios Kordalis, Athina Pyrpasopoulou, Christodoulos Papadopoulos, Michael Doumas
Affiliations
- PMID: 36027022
- DOI: 10.1097/01.hjh.0000837084.91831.2a
Abstract
Objective: A number of studies have indicated a deleterious effect of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection on endothelial function of enrolled subjects, further impairing during post-infectious stage. Endothelial function might indeed have a prognostic role in coronavirus disease-19 (COVID-19). Herein we sought to determine the effect of SARS-CoV-2 on endothelial function as quantified by flow-mediated dilation (FMD).
Design and method: We searched the PubMed database from inception till 21st December, 2021, for observational studies assessing the impact of SARS-CoV-2 on endothelial function either in the in-hospital or the outpatient setting. We set as primary efficacy outcome the mean difference in FMD between infected patients and healthy controls.
Results: We pooled data from 5 observational studies in a total of 541 enrolled subjects. One study enrolled children, while the rest 4 enrolled adults. Overall, COVID-19 induced a significant decrease in FMD by 3.29% (95% CI; -4.57 to -2.01, I2 = 81%) compared to healthy controls.
Conclusions: Despite being preliminary, these results suggest a significant effect of SARS-CoV-2 on endothelial system, leading to significant endothelial dysfunction. Prognostic implications of that effect have to be determined in prospective studies.