tetano
Editor, Senior Moderator
J Hypertens
. 2022 Jun 1;40(Suppl 1):e169.
doi: 10.1097/01.hjh.0000837088.20576.eb.
CORONAVIRUS DISEASE-2019 IS ASSOCIATED WITH ARTERIAL STIFFNESS IMPAIRMENT: A META-ANALYSIS OF OBSERVATIONAL STUDIES
Dimitrios Patoulias[SUP] 1 [/SUP], Alexandra Katsimardou[SUP] 1 [/SUP], Konstantinos Imprialos[SUP] 1 [/SUP], Konstantinos Stavropoulos[SUP] 1 [/SUP], Asimina Sviggou[SUP] 1 [/SUP], Asterios Aidinis[SUP] 1 [/SUP], Vasilios Kordalis[SUP] 1 [/SUP], Athina Pyrpasopoulou[SUP] 1 [/SUP], Christodoulos Papadopoulos[SUP] 2 [/SUP], Michael Doumas[SUP] 1 [/SUP]
Affiliations
Abstract
Objective: Coronavirus disease-2019 (COVID-19) still represents a global nightmare, associated with significant morbidity and mortality, despite the development of effective vaccines. Cardiovascular complications are frequent among infected subjects. Arterial stiffness is an accurate prognostic marker of cardiovascular disease, with pulse wave velocity (PWV) being the gold-standard for arterial stiffness quantification. Herein we sought to determine whether there is a significant difference in PWV between COVID-19 positive subjects and healthy controls.
Design and method: We searched two major databases (PubMed and Cochrane Library) from inception to 10th December 2021 for observational studies assessing the effect of SARS-CoV-2 on arterial stiffness. We set as primary efficacy outcome the mean difference in PWV between infected patients and healthy controls.
Results: We finally pooled data from 4 observational studies in a total of 327 subjects. SARS-CoV-2 positive patients exhibited significantly greater PWV compared to healthy controls (mean difference = 1.32 m/s, 95 CI; 0.46 - 2.18, I2 = 62%, p = 0.0003).
Conclusions: COVID-19 is associated with significantly increased PWV. However, it remains unclear whether PWV could be a significant prognostic marker of cardiovascular complications among infected subjects.
. 2022 Jun 1;40(Suppl 1):e169.
doi: 10.1097/01.hjh.0000837088.20576.eb.
CORONAVIRUS DISEASE-2019 IS ASSOCIATED WITH ARTERIAL STIFFNESS IMPAIRMENT: A META-ANALYSIS OF OBSERVATIONAL STUDIES
Dimitrios Patoulias[SUP] 1 [/SUP], Alexandra Katsimardou[SUP] 1 [/SUP], Konstantinos Imprialos[SUP] 1 [/SUP], Konstantinos Stavropoulos[SUP] 1 [/SUP], Asimina Sviggou[SUP] 1 [/SUP], Asterios Aidinis[SUP] 1 [/SUP], Vasilios Kordalis[SUP] 1 [/SUP], Athina Pyrpasopoulou[SUP] 1 [/SUP], Christodoulos Papadopoulos[SUP] 2 [/SUP], Michael Doumas[SUP] 1 [/SUP]
Affiliations
- PMID: 36027023
- DOI: 10.1097/01.hjh.0000837088.20576.eb
Abstract
Objective: Coronavirus disease-2019 (COVID-19) still represents a global nightmare, associated with significant morbidity and mortality, despite the development of effective vaccines. Cardiovascular complications are frequent among infected subjects. Arterial stiffness is an accurate prognostic marker of cardiovascular disease, with pulse wave velocity (PWV) being the gold-standard for arterial stiffness quantification. Herein we sought to determine whether there is a significant difference in PWV between COVID-19 positive subjects and healthy controls.
Design and method: We searched two major databases (PubMed and Cochrane Library) from inception to 10th December 2021 for observational studies assessing the effect of SARS-CoV-2 on arterial stiffness. We set as primary efficacy outcome the mean difference in PWV between infected patients and healthy controls.
Results: We finally pooled data from 4 observational studies in a total of 327 subjects. SARS-CoV-2 positive patients exhibited significantly greater PWV compared to healthy controls (mean difference = 1.32 m/s, 95 CI; 0.46 - 2.18, I2 = 62%, p = 0.0003).
Conclusions: COVID-19 is associated with significantly increased PWV. However, it remains unclear whether PWV could be a significant prognostic marker of cardiovascular complications among infected subjects.