tetano
Editor, Senior Moderator
J Hypertens
. 2023 Sep 1.
doi: 10.1097/HJH.0000000000003522. Online ahead of print. Increased blood pressure after nonsevere COVID-19
Christian Schmidt-Lauber[SUP] 1 2 3 [/SUP], Elisa Alba Schmidt[SUP] 1 2 [/SUP], Sonja Hänzelmann[SUP] 1 2 4 [/SUP], Elina L Petersen[SUP] 5 [/SUP], Christian-Alexander Behrendt[SUP] 5 [/SUP], Raphael Twerenbold[SUP] 5 6 7 [/SUP], Stefan Blankenberg[SUP] 5 6 [/SUP], Tobias B Huber[SUP] 1 2 [/SUP], Ulrich O Wenzel[SUP] 1 2 [/SUP]
Affiliations
Background: Various sequelae have been described after nonsevere coronavirus disease 2019 (COVID-19), but knowledge on postacute effects on blood pressure is limited.
Methods: This is a cross-sectional analysis of blood pressure profiles in individuals after nonsevere COVID-19 compared with matched population-based individuals without prior COVID-19. Data were derived from the ongoing and prospective Hamburg City Health Study, a population-based study in Hamburg, Germany, and its associated COVID-19 program, which included individuals at least 4 months after COVID-19. Matching was performed by age, sex, education, and preexisting hypertension in a 1 : 4 ratio.
Results: Four hundred and thirty-two individuals after COVID-19 (mean age 56.1 years) were matched to 1728 controls without prior COVID-19 (56.2 years). About 92.8% of COVID-19 courses were mild or moderate, only 7.2% were hospitalized, and no individual had been treated on an intensive care unit. Even after adjustment for relevant competing risk factors, DBP [+4.7 mmHg, 95% confidence interval (95% CI) 3.97-5.7, P < 0.001] was significantly higher in individuals after COVID-19. For SBP, a trend towards increased values was observed (+1.4 mmHg, 95% CI -0.4 to 3.2, P = 0.120). Hypertensive blood pressures at least 130/80 mmHg (according to the ACC/AHA guideline) and at least 140/90 mmHg (ESC/ESH guideline) occurred significantly more often in individuals after COVID-19 than matched controls (odds ratio 2.0, 95% CI 1.5-2.7, P < 0.001 and odds ratio 1.6, 95% CI 1.3-2.0, P < 0.001, respectively), mainly driven by changes in DBP.
Conclusion: Blood pressure is higher in individuals after nonsevere COVID-19 compared with uninfected individuals suggesting a significant hypertensive sequela.
. 2023 Sep 1.
doi: 10.1097/HJH.0000000000003522. Online ahead of print. Increased blood pressure after nonsevere COVID-19
Christian Schmidt-Lauber[SUP] 1 2 3 [/SUP], Elisa Alba Schmidt[SUP] 1 2 [/SUP], Sonja Hänzelmann[SUP] 1 2 4 [/SUP], Elina L Petersen[SUP] 5 [/SUP], Christian-Alexander Behrendt[SUP] 5 [/SUP], Raphael Twerenbold[SUP] 5 6 7 [/SUP], Stefan Blankenberg[SUP] 5 6 [/SUP], Tobias B Huber[SUP] 1 2 [/SUP], Ulrich O Wenzel[SUP] 1 2 [/SUP]
Affiliations
- PMID: 37682048
- DOI: 10.1097/HJH.0000000000003522
Background: Various sequelae have been described after nonsevere coronavirus disease 2019 (COVID-19), but knowledge on postacute effects on blood pressure is limited.
Methods: This is a cross-sectional analysis of blood pressure profiles in individuals after nonsevere COVID-19 compared with matched population-based individuals without prior COVID-19. Data were derived from the ongoing and prospective Hamburg City Health Study, a population-based study in Hamburg, Germany, and its associated COVID-19 program, which included individuals at least 4 months after COVID-19. Matching was performed by age, sex, education, and preexisting hypertension in a 1 : 4 ratio.
Results: Four hundred and thirty-two individuals after COVID-19 (mean age 56.1 years) were matched to 1728 controls without prior COVID-19 (56.2 years). About 92.8% of COVID-19 courses were mild or moderate, only 7.2% were hospitalized, and no individual had been treated on an intensive care unit. Even after adjustment for relevant competing risk factors, DBP [+4.7 mmHg, 95% confidence interval (95% CI) 3.97-5.7, P < 0.001] was significantly higher in individuals after COVID-19. For SBP, a trend towards increased values was observed (+1.4 mmHg, 95% CI -0.4 to 3.2, P = 0.120). Hypertensive blood pressures at least 130/80 mmHg (according to the ACC/AHA guideline) and at least 140/90 mmHg (ESC/ESH guideline) occurred significantly more often in individuals after COVID-19 than matched controls (odds ratio 2.0, 95% CI 1.5-2.7, P < 0.001 and odds ratio 1.6, 95% CI 1.3-2.0, P < 0.001, respectively), mainly driven by changes in DBP.
Conclusion: Blood pressure is higher in individuals after nonsevere COVID-19 compared with uninfected individuals suggesting a significant hypertensive sequela.