tetano
Editor, Senior Moderator
J Glob Health
. 2021 Mar 27;11:05006.
doi: 10.7189/jogh.11.05006.
Sudden death of COVID-19 patients in Wuhan, China: A retrospective cohort study
Nan Yang[SUP] 1 [/SUP], Kunming Tian[SUP] 2 [/SUP], Meng Jin[SUP] 3 [/SUP], Xu Zhang[SUP] 4 [/SUP], Fengqin Zhang[SUP] 5 [/SUP], Xiuquan Shi[SUP] 6 [/SUP], Xiaoyang Wang[SUP] 1 [/SUP], Siyuan Niu[SUP] 1 [/SUP], Jing Shi[SUP] 5 [/SUP], Ke Hu[SUP] 3 [/SUP], Kui Liu[SUP] 5 [/SUP], Ping Peng[SUP] 7 [/SUP], Ying Wang[SUP] 8 [/SUP], Huilan Zhang[SUP] 5 [/SUP], Jianbo Tian[SUP] 1 [/SUP]
Affiliations
Abstract
Background: In December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan city and rapidly spread throughout China. So far, it has caused ~ 4000 deaths in this country. We aimed to systematically characterize clinical features and determine risk factors of sudden death for COVID-19 patients.
Methods: Deceased patients with COVID-19 in Tongji hospital from January 22 to March 23, 2020 were extracted. Patients who died within 24 hours after admission were identified as sudden deaths, and the others formed non-sudden deaths. The differences in clinical characteristics between the two groups were estimated. Risk factors associated with sudden deaths were explored by logistic regression.
Results: 281 deceased patients were enrolled in this study. Sudden death occurred in 28 (10.0%) patients, including 4 (14.3%) admitted to the intensive care unit. Fatigue was more common in sudden deaths (11, 47.8%) than in non-sudden deaths (40, 17.2%). Both the count and percentage of eosinophils were lower in sudden deaths than that in non-sudden deaths (P = 0.006 and P = 0.004). Compared with non-sudden deaths, sudden deaths had higher plasma levels of procalcitonin, C-reactive protein, D-dimer, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, lactate dehydrogenase, alkaline phosphatase and N-terminal pro-brain natriuretic peptide. There were not significant differences in gender, age, chest CT image features and comorbidities observed.
Conclusions: The differences between the two groups suggested more severe systemic inflammation, multi-organ dysfunction, especially impaired liver and heart function in COVID-19 patients who died suddenly after admission. More researches are needed to verify these points.
. 2021 Mar 27;11:05006.
doi: 10.7189/jogh.11.05006.
Sudden death of COVID-19 patients in Wuhan, China: A retrospective cohort study
Nan Yang[SUP] 1 [/SUP], Kunming Tian[SUP] 2 [/SUP], Meng Jin[SUP] 3 [/SUP], Xu Zhang[SUP] 4 [/SUP], Fengqin Zhang[SUP] 5 [/SUP], Xiuquan Shi[SUP] 6 [/SUP], Xiaoyang Wang[SUP] 1 [/SUP], Siyuan Niu[SUP] 1 [/SUP], Jing Shi[SUP] 5 [/SUP], Ke Hu[SUP] 3 [/SUP], Kui Liu[SUP] 5 [/SUP], Ping Peng[SUP] 7 [/SUP], Ying Wang[SUP] 8 [/SUP], Huilan Zhang[SUP] 5 [/SUP], Jianbo Tian[SUP] 1 [/SUP]
Affiliations
- PMID: 33828847
- PMCID: PMC8005311
- DOI: 10.7189/jogh.11.05006
Abstract
Background: In December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan city and rapidly spread throughout China. So far, it has caused ~ 4000 deaths in this country. We aimed to systematically characterize clinical features and determine risk factors of sudden death for COVID-19 patients.
Methods: Deceased patients with COVID-19 in Tongji hospital from January 22 to March 23, 2020 were extracted. Patients who died within 24 hours after admission were identified as sudden deaths, and the others formed non-sudden deaths. The differences in clinical characteristics between the two groups were estimated. Risk factors associated with sudden deaths were explored by logistic regression.
Results: 281 deceased patients were enrolled in this study. Sudden death occurred in 28 (10.0%) patients, including 4 (14.3%) admitted to the intensive care unit. Fatigue was more common in sudden deaths (11, 47.8%) than in non-sudden deaths (40, 17.2%). Both the count and percentage of eosinophils were lower in sudden deaths than that in non-sudden deaths (P = 0.006 and P = 0.004). Compared with non-sudden deaths, sudden deaths had higher plasma levels of procalcitonin, C-reactive protein, D-dimer, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, lactate dehydrogenase, alkaline phosphatase and N-terminal pro-brain natriuretic peptide. There were not significant differences in gender, age, chest CT image features and comorbidities observed.
Conclusions: The differences between the two groups suggested more severe systemic inflammation, multi-organ dysfunction, especially impaired liver and heart function in COVID-19 patients who died suddenly after admission. More researches are needed to verify these points.