Giuseppe
Emeritus
[Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]
J Gen Virol. 2013 Nov 6. [Epub ahead of print]
Wild type and innate immune deficient mice are not susceptible to the Middle East Respiratory Syndrome Coronavirus.
Coleman CM, Matthews KL, Goicochea L, Frieman MB.
Source: University of Maryland;
Abstract
The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a newly emerging highly pathogenic virus causing almost 50% lethality in infected individuals. The development of a small animal model is critical for the understanding of this virus and to aid in development of countermeasures against MERS-CoV. We find that BALB/c, 129/SvEv and 129/SvEv STAT1 knockout mice are not permissive to MERS-CoV infection. The lack of infection may be do to the low level of mRNA and protein for the MERS-CoV receptor, Dipeptidyl Peptidase 4 (DPP4), in the lungs of mice. The low level of DPP4 in the lungs likely contributes to the lack of viral replication in these mouse models and suggests that a transgenic mouse model expressing DPP4 to higher levels is necessary to create a mouse model for MERS-CoV.
KEYWORDS: Coronavirus, MERS, infection, pathogenesis
PMID: 24197535 [PubMed - as supplied by publisher]
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J Gen Virol. 2013 Nov 6. [Epub ahead of print]
Wild type and innate immune deficient mice are not susceptible to the Middle East Respiratory Syndrome Coronavirus.
Coleman CM, Matthews KL, Goicochea L, Frieman MB.
Source: University of Maryland;
Abstract
The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a newly emerging highly pathogenic virus causing almost 50% lethality in infected individuals. The development of a small animal model is critical for the understanding of this virus and to aid in development of countermeasures against MERS-CoV. We find that BALB/c, 129/SvEv and 129/SvEv STAT1 knockout mice are not permissive to MERS-CoV infection. The lack of infection may be do to the low level of mRNA and protein for the MERS-CoV receptor, Dipeptidyl Peptidase 4 (DPP4), in the lungs of mice. The low level of DPP4 in the lungs likely contributes to the lack of viral replication in these mouse models and suggests that a transgenic mouse model expressing DPP4 to higher levels is necessary to create a mouse model for MERS-CoV.
KEYWORDS: Coronavirus, MERS, infection, pathogenesis
PMID: 24197535 [PubMed - as supplied by publisher]
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