Giuseppe
Emeritus
Homeostatic proliferation generates long-lived natural killer cells that respond against viral infection (J Exp Med., abstract, edited)
[Source: Journal of Experimental Medicine, full text: <cite cite="http://jem.rupress.org/content/208/2/357.short?rss=1">Homeostatic proliferation generates long-lived natural killer cells that respond against viral infection ? JEM</cite>. Abstract, edited.]
2011 Archive - 14 February
Sun et al. 208 (2): 357
Published January 24, 2011 // JEM vol. 208 no. 2 357-368
The Rockefeller University Press, doi: 10.1084/jem.20100479
? 2011 Sun et al.
Homeostatic proliferation generates long-lived natural killer cells that respond against viral infection
1. Joseph C. Sun 1, 2. Joshua N. Beilke 2, 3. Natalie A. Bezman 2, and 4. Lewis L. Lanier 2
Author Affiliations
1. 1Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065
2. 2Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94143
1. CORRESPONDENCE Lewis L. Lanier: Lewis.Lanier@ucsf.edu
Abstract
Cells of the immune system undergo homeostatic proliferation during times of lymphopenia induced by certain viral infections or caused by chemotherapy and radiation treatment. Natural killer (NK) cells are no exception and can rapidly expand in number when placed into an environment devoid of these cells. We explored the lifespan and function of mouse NK cells that have undergone homeostatic proliferation in various settings of immunodeficiency. Adoptive transfer of mature NK cells into lymphopenic mice resulted in the generation of a long-lived population of NK cells. These homeostasis-driven NK cells reside in both lymphoid and nonlymphoid organs for >6 mo and, similar to memory T cells, self-renew and slowly turn over at steady state. Furthermore, homeostatically expanded NK cells retained their functionality many months after initial transfer and responded robustly to viral infection. These findings highlight the ability of mature NK cells to self-renew and possibly persist in the host for months or years and might be of clinical importance during NK cell adoptive immunotherapy for the treatment of certain cancers.
* Submitted: 9 March 2010
* Accepted: 21 December 2010
This article is distributed under the terms of an Attribution?Noncommercial?Share Alike?No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution?Noncommercial?Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
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[Source: Journal of Experimental Medicine, full text: <cite cite="http://jem.rupress.org/content/208/2/357.short?rss=1">Homeostatic proliferation generates long-lived natural killer cells that respond against viral infection ? JEM</cite>. Abstract, edited.]
2011 Archive - 14 February
Sun et al. 208 (2): 357
Published January 24, 2011 // JEM vol. 208 no. 2 357-368
The Rockefeller University Press, doi: 10.1084/jem.20100479
? 2011 Sun et al.
Homeostatic proliferation generates long-lived natural killer cells that respond against viral infection
1. Joseph C. Sun 1, 2. Joshua N. Beilke 2, 3. Natalie A. Bezman 2, and 4. Lewis L. Lanier 2
Author Affiliations
1. 1Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065
2. 2Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94143
1. CORRESPONDENCE Lewis L. Lanier: Lewis.Lanier@ucsf.edu
Abstract
Cells of the immune system undergo homeostatic proliferation during times of lymphopenia induced by certain viral infections or caused by chemotherapy and radiation treatment. Natural killer (NK) cells are no exception and can rapidly expand in number when placed into an environment devoid of these cells. We explored the lifespan and function of mouse NK cells that have undergone homeostatic proliferation in various settings of immunodeficiency. Adoptive transfer of mature NK cells into lymphopenic mice resulted in the generation of a long-lived population of NK cells. These homeostasis-driven NK cells reside in both lymphoid and nonlymphoid organs for >6 mo and, similar to memory T cells, self-renew and slowly turn over at steady state. Furthermore, homeostatically expanded NK cells retained their functionality many months after initial transfer and responded robustly to viral infection. These findings highlight the ability of mature NK cells to self-renew and possibly persist in the host for months or years and might be of clinical importance during NK cell adoptive immunotherapy for the treatment of certain cancers.
* Submitted: 9 March 2010
* Accepted: 21 December 2010
This article is distributed under the terms of an Attribution?Noncommercial?Share Alike?No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution?Noncommercial?Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
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