tetano
Editor, Senior Moderator
J Diabetes
. 2021 Jan 23.
doi: 10.1111/1753-0407.13158. Online ahead of print.
Predictors of Mortality in a Multi-Racial Urban Cohort of Persons with Type 2 Diabetes and Novel Coronavirus 19
Alyson K Myers[SUP] 1 2 3 4 [/SUP], Tara S Kim[SUP] 3 5 [/SUP], Xu Zhu[SUP] 2 4 6 [/SUP], Yan Liu[SUP] 2 [/SUP], Michael Qiu[SUP] 2 [/SUP], Renee Pekmezaris[SUP] 2 3 4 6 [/SUP]
Affiliations
Abstract
Objective: Diabetes has been identified as a risk factor for intubation and mortality in patients with SARS Co-V 2 (COVID-19). We seek to examine the impact of clinical variables such as Hemoglobin A1c (HbA1c) on mortality and need for intubation, as well as demographic variables such as age, sex and race on persons with type 2 diabetes and COVID-19.
Research design and methods: Analyses were conducted on 4413 patients with an ICD-10 diagnosis of type 2 diabetes and COVID-19. Survival analysis was conducted using Kaplan- Meier curves and the log-rank test to compare subgroup analyses.
Results: In this multi-variate analyses, male gender, older age and hyperglycemia at admission were associated with increased mortality and intubation, but this was not seen for race, ethnicity, insurance type or HbA1c. Based on Kaplan-Meier analysis, having comorbid conditions such as hypertension, chronic kidney disease and coronary artery disease were associated with a statistically significant increased risk of mortality.
Conclusions: Glycemic levels at admission have a greater impact on health outcomes than HbA1c. Older men and those with comorbid disease are also at greater risk for mortality. Further longitudinal studies need to be done to evaluate the impact of COVID-19 on type 2 diabetes.
Keywords: COVID-19; Glycemic Control; Mortality; Type 2 Diabetes; Urban Population.
. 2021 Jan 23.
doi: 10.1111/1753-0407.13158. Online ahead of print.
Predictors of Mortality in a Multi-Racial Urban Cohort of Persons with Type 2 Diabetes and Novel Coronavirus 19
Alyson K Myers[SUP] 1 2 3 4 [/SUP], Tara S Kim[SUP] 3 5 [/SUP], Xu Zhu[SUP] 2 4 6 [/SUP], Yan Liu[SUP] 2 [/SUP], Michael Qiu[SUP] 2 [/SUP], Renee Pekmezaris[SUP] 2 3 4 6 [/SUP]
Affiliations
- PMID: 33486896
- DOI: 10.1111/1753-0407.13158
Abstract
Objective: Diabetes has been identified as a risk factor for intubation and mortality in patients with SARS Co-V 2 (COVID-19). We seek to examine the impact of clinical variables such as Hemoglobin A1c (HbA1c) on mortality and need for intubation, as well as demographic variables such as age, sex and race on persons with type 2 diabetes and COVID-19.
Research design and methods: Analyses were conducted on 4413 patients with an ICD-10 diagnosis of type 2 diabetes and COVID-19. Survival analysis was conducted using Kaplan- Meier curves and the log-rank test to compare subgroup analyses.
Results: In this multi-variate analyses, male gender, older age and hyperglycemia at admission were associated with increased mortality and intubation, but this was not seen for race, ethnicity, insurance type or HbA1c. Based on Kaplan-Meier analysis, having comorbid conditions such as hypertension, chronic kidney disease and coronary artery disease were associated with a statistically significant increased risk of mortality.
Conclusions: Glycemic levels at admission have a greater impact on health outcomes than HbA1c. Older men and those with comorbid disease are also at greater risk for mortality. Further longitudinal studies need to be done to evaluate the impact of COVID-19 on type 2 diabetes.
Keywords: COVID-19; Glycemic Control; Mortality; Type 2 Diabetes; Urban Population.