tetano
Editor, Senior Moderator
J Cyst Fibros
. 2024 Aug 26:S1569-1993(24)00804-X.
doi: 10.1016/j.jcf.2024.07.019. Online ahead of print. Impact of COVID-19 infection on lung function and nutritional status amongst individuals with cystic fibrosis: A global cohort study
Julie Semenchuk[SUP] 1 [/SUP], Yumi Naito[SUP] 2 [/SUP], Susan C Charman[SUP] 2 [/SUP], Siobhán B Carr[SUP] 3 [/SUP], Stephanie Y Cheng[SUP] 4 [/SUP], Bruce C Marshall[SUP] 5 [/SUP], Albert Faro[SUP] 5 [/SUP], Alexander Elbert[SUP] 5 [/SUP], Hector H Gutierrez[SUP] 6 [/SUP], Christopher H Goss[SUP] 7 [/SUP], Bulent Karadag[SUP] 8 [/SUP], Pierre-Régis Burgel[SUP] 9 [/SUP], Carla Colombo[SUP] 10 [/SUP], Marco Salvatore[SUP] 11 [/SUP], Rita Padoan[SUP] 12 [/SUP], Géraldine Daneau[SUP] 13 [/SUP], Satenik Harutyunyan[SUP] 14 [/SUP], Nataliya Kashirskaya[SUP] 15 [/SUP], Laura Kirwan[SUP] 16 [/SUP], Peter G Middleton[SUP] 17 [/SUP], Rasa Ruseckaite[SUP] 18 [/SUP], Isabelle de Monestrol[SUP] 19 [/SUP], Lutz Naehrlich[SUP] 20 [/SUP], Pedro Mondejar-Lopez[SUP] 21 [/SUP], Andreas Jung[SUP] 22 [/SUP], Jacqui van Rens[SUP] 23 [/SUP], Egil Bakkeheim[SUP] 24 [/SUP], Annalisa Orenti[SUP] 25 [/SUP], Domenique Zomer-van Ommen[SUP] 26 [/SUP], Luiz Vicente Rf da Silva-Filho[SUP] 27 [/SUP], Flavia Fonseca Fernandes[SUP] 28 [/SUP], Marco Zampoli[SUP] 29 [/SUP], Anne L Stephenson[SUP] 30 [/SUP]; Global CF Registry Collaboration
Affiliations
Background: Factors associated with severe COVID-19 infection have been identified; however, the impact of infection on longer-term outcomes is unclear. The objective of this study was to examine the impact of COVID-19 infection on the trajectory of lung function and nutritional status in people with cystic fibrosis (pwCF).
Methods: This is a retrospective global cohort study of pwCF who had confirmed COVID-19 infection diagnosed between January 1, 2020 and December 31, 2021. Forced expiratory volume in one second percent predicted (ppFEV[SUB]1[/SUB]) and body mass index (BMI) twelve months prior to and following a diagnosis of COVID-19 were recorded. Change in mean ppFEV[SUB]1[/SUB] and BMI were compared using a t-test. A linear mixed-effects model was used to estimate change over time and to compare the rate of change before and after infection.
Results: A total of 6,500 cases of COVID-19 in pwCF from 33 countries were included for analysis. The mean difference in ppFEV[SUB]1[/SUB] pre- and post-infection was 1.4 %, (95 % CI 1.1, 1.7). In those not on modulators, the difference in rate of change pre- and post-infection was 1.34 %, (95 % CI -0.88, 3.56) per year (p = 0.24) and -0.74 % (-1.89, 0.41) per year (p = 0.21) for those on elexacaftor/tezacaftor/ivacaftor. No clinically significant change was noted in BMI or BMI percentile before and after COVID-19 infection.
Conclusions: No clinically meaningful impact on lung function and BMI trajectory in the year following infection with COVID-19 was identified. This work highlights the ability of the global CF community to unify and address critical issues facing pwCF.
Keywords: COVID-19; Coronavirus; Cystic fibrosis.
. 2024 Aug 26:S1569-1993(24)00804-X.
doi: 10.1016/j.jcf.2024.07.019. Online ahead of print. Impact of COVID-19 infection on lung function and nutritional status amongst individuals with cystic fibrosis: A global cohort study
Julie Semenchuk[SUP] 1 [/SUP], Yumi Naito[SUP] 2 [/SUP], Susan C Charman[SUP] 2 [/SUP], Siobhán B Carr[SUP] 3 [/SUP], Stephanie Y Cheng[SUP] 4 [/SUP], Bruce C Marshall[SUP] 5 [/SUP], Albert Faro[SUP] 5 [/SUP], Alexander Elbert[SUP] 5 [/SUP], Hector H Gutierrez[SUP] 6 [/SUP], Christopher H Goss[SUP] 7 [/SUP], Bulent Karadag[SUP] 8 [/SUP], Pierre-Régis Burgel[SUP] 9 [/SUP], Carla Colombo[SUP] 10 [/SUP], Marco Salvatore[SUP] 11 [/SUP], Rita Padoan[SUP] 12 [/SUP], Géraldine Daneau[SUP] 13 [/SUP], Satenik Harutyunyan[SUP] 14 [/SUP], Nataliya Kashirskaya[SUP] 15 [/SUP], Laura Kirwan[SUP] 16 [/SUP], Peter G Middleton[SUP] 17 [/SUP], Rasa Ruseckaite[SUP] 18 [/SUP], Isabelle de Monestrol[SUP] 19 [/SUP], Lutz Naehrlich[SUP] 20 [/SUP], Pedro Mondejar-Lopez[SUP] 21 [/SUP], Andreas Jung[SUP] 22 [/SUP], Jacqui van Rens[SUP] 23 [/SUP], Egil Bakkeheim[SUP] 24 [/SUP], Annalisa Orenti[SUP] 25 [/SUP], Domenique Zomer-van Ommen[SUP] 26 [/SUP], Luiz Vicente Rf da Silva-Filho[SUP] 27 [/SUP], Flavia Fonseca Fernandes[SUP] 28 [/SUP], Marco Zampoli[SUP] 29 [/SUP], Anne L Stephenson[SUP] 30 [/SUP]; Global CF Registry Collaboration
Affiliations
- PMID: 39191560
- DOI: 10.1016/j.jcf.2024.07.019
Background: Factors associated with severe COVID-19 infection have been identified; however, the impact of infection on longer-term outcomes is unclear. The objective of this study was to examine the impact of COVID-19 infection on the trajectory of lung function and nutritional status in people with cystic fibrosis (pwCF).
Methods: This is a retrospective global cohort study of pwCF who had confirmed COVID-19 infection diagnosed between January 1, 2020 and December 31, 2021. Forced expiratory volume in one second percent predicted (ppFEV[SUB]1[/SUB]) and body mass index (BMI) twelve months prior to and following a diagnosis of COVID-19 were recorded. Change in mean ppFEV[SUB]1[/SUB] and BMI were compared using a t-test. A linear mixed-effects model was used to estimate change over time and to compare the rate of change before and after infection.
Results: A total of 6,500 cases of COVID-19 in pwCF from 33 countries were included for analysis. The mean difference in ppFEV[SUB]1[/SUB] pre- and post-infection was 1.4 %, (95 % CI 1.1, 1.7). In those not on modulators, the difference in rate of change pre- and post-infection was 1.34 %, (95 % CI -0.88, 3.56) per year (p = 0.24) and -0.74 % (-1.89, 0.41) per year (p = 0.21) for those on elexacaftor/tezacaftor/ivacaftor. No clinically significant change was noted in BMI or BMI percentile before and after COVID-19 infection.
Conclusions: No clinically meaningful impact on lung function and BMI trajectory in the year following infection with COVID-19 was identified. This work highlights the ability of the global CF community to unify and address critical issues facing pwCF.
Keywords: COVID-19; Coronavirus; Cystic fibrosis.