tetano
Editor, Senior Moderator
J Crit Care Med (Targu Mures)
. 2021 Aug 5;7(3):211-216.
doi: 10.2478/jccm-2021-0021. eCollection 2021 Jul.
Impact of the Severity of Liver Injury in COVID-19 Patients Admitted to an Intensive Care Unit During the SARS-CoV2 Pandemic Outbreak
Adina Roman[SUP] 1 2 3 [/SUP], Septimiu Moldovan[SUP] 2 [/SUP], Ario Santini[SUP] 2 [/SUP], Mircea Stoian[SUP] 1 2 [/SUP], Daniela Dobru[SUP] 1 2 [/SUP]
Affiliations
Abstract
Introduction: The World Health Organization (WHO) identified a novel coronavirus, originating in Wuhan, China, in December 2019, as a pneumonia causing pathogen. Epidemiological data in Romania show more than 450.000 confirmed patients, with a constant number of approximately 10% admission in intensive care unit.
Method: A retrospective, observational study was conducted from 1st March to 30th October 2020, comprising 657 patients, confirmed as having COVID-19, and who had been admitted to the intensive care unit of the Mures County Clinical Hospital, Tîrgu Mures, Romania, which had been designated as a support hospital during the pandemic. Patients who presented at admission or developed abnormal liver function tests in the first seven days of admission, were included in the study; patients with pre-existing liver disease, were excluded.
Results: The mean (SD) age of patients included in the study was 59.41 (14.66) years with a male: female ratio of 1.51:1. Survivor status, defined as patients discharged from the intensive care unit, was significantly associated with parameters such as age, leukocyte count, albumin level, glycaemia level (p<0.05 for all parameters.).
Conclusions: Liver injury expressed through liver function tests cannot solely constitute a prognostic factor for COVID-19 patients, but its presence in critically ill patients should be further investigated and included in future guideline protocols.
Keywords: COVID-19; SARS-COV2; liver injury; pandemic outbreak.
. 2021 Aug 5;7(3):211-216.
doi: 10.2478/jccm-2021-0021. eCollection 2021 Jul.
Impact of the Severity of Liver Injury in COVID-19 Patients Admitted to an Intensive Care Unit During the SARS-CoV2 Pandemic Outbreak
Adina Roman[SUP] 1 2 3 [/SUP], Septimiu Moldovan[SUP] 2 [/SUP], Ario Santini[SUP] 2 [/SUP], Mircea Stoian[SUP] 1 2 [/SUP], Daniela Dobru[SUP] 1 2 [/SUP]
Affiliations
- PMID: 34722924
- PMCID: PMC8519387
- DOI: 10.2478/jccm-2021-0021
Abstract
Introduction: The World Health Organization (WHO) identified a novel coronavirus, originating in Wuhan, China, in December 2019, as a pneumonia causing pathogen. Epidemiological data in Romania show more than 450.000 confirmed patients, with a constant number of approximately 10% admission in intensive care unit.
Method: A retrospective, observational study was conducted from 1st March to 30th October 2020, comprising 657 patients, confirmed as having COVID-19, and who had been admitted to the intensive care unit of the Mures County Clinical Hospital, Tîrgu Mures, Romania, which had been designated as a support hospital during the pandemic. Patients who presented at admission or developed abnormal liver function tests in the first seven days of admission, were included in the study; patients with pre-existing liver disease, were excluded.
Results: The mean (SD) age of patients included in the study was 59.41 (14.66) years with a male: female ratio of 1.51:1. Survivor status, defined as patients discharged from the intensive care unit, was significantly associated with parameters such as age, leukocyte count, albumin level, glycaemia level (p<0.05 for all parameters.).
Conclusions: Liver injury expressed through liver function tests cannot solely constitute a prognostic factor for COVID-19 patients, but its presence in critically ill patients should be further investigated and included in future guideline protocols.
Keywords: COVID-19; SARS-COV2; liver injury; pandemic outbreak.