tetano
Editor, Senior Moderator
J Community Hosp Intern Med Perspect
. 2021 Nov 15;11(6):733-739.
doi: 10.1080/20009666.2021.1974665. eCollection 2021.
COVID-19 reinfection: the role of natural immunity, vaccines, and variants
Bao Y Sciscent[SUP] 1 [/SUP], Caroline D Eisele[SUP] 1 [/SUP], Lisa Ho[SUP] 1 [/SUP], Steven D King[SUP] 1 [/SUP], Rohit Jain[SUP] 2 [/SUP], Reshma R Golamari[SUP] 2 [/SUP]
Affiliations
Abstract
The COVID-19 pandemic has altered innumerable lives. Although recent mass vaccinations offer a glimmer of hope, the rising death toll and new variants continue to dominate the current scenario. As we begin to understand more about SARS-CoV-2 infections, the territory of reinfections with COVID-19 remains unexplored. In this review, we will discuss several aspects of reinfection: (a) How is COVID-19 reinfection characterized? (b) Does prior literature differentiate between reinfection and reactivation? (c) What SARS-CoV-2 strains do the vaccines target and can they protect against new strains? Larger and longer timeline studies are needed to understand reinfection risks. With the ongoing distribution of the SARS-CoV-2 vaccines to provide protection, the understanding of the possibility for SARS-CoV-2 reinfection remains critical. Abbreviations CDC: Centers for Disease ControlSARS-CoV-2: Severe acute respiratory syndrome coronavirus 2COVID-19: Coronavirus disease 2019RT-PCR: Reverse Transcription Polymerase Chain ReactionPASC: Post-Acute Sequelae of SARS-CoV-2 infection.
Keywords: COVID-19; COVID-19 immunity; COVID-19 vaccination; SARS-CoV-2; reinfection.
. 2021 Nov 15;11(6):733-739.
doi: 10.1080/20009666.2021.1974665. eCollection 2021.
COVID-19 reinfection: the role of natural immunity, vaccines, and variants
Bao Y Sciscent[SUP] 1 [/SUP], Caroline D Eisele[SUP] 1 [/SUP], Lisa Ho[SUP] 1 [/SUP], Steven D King[SUP] 1 [/SUP], Rohit Jain[SUP] 2 [/SUP], Reshma R Golamari[SUP] 2 [/SUP]
Affiliations
- PMID: 34804382
- PMCID: PMC8604456
- DOI: 10.1080/20009666.2021.1974665
Abstract
The COVID-19 pandemic has altered innumerable lives. Although recent mass vaccinations offer a glimmer of hope, the rising death toll and new variants continue to dominate the current scenario. As we begin to understand more about SARS-CoV-2 infections, the territory of reinfections with COVID-19 remains unexplored. In this review, we will discuss several aspects of reinfection: (a) How is COVID-19 reinfection characterized? (b) Does prior literature differentiate between reinfection and reactivation? (c) What SARS-CoV-2 strains do the vaccines target and can they protect against new strains? Larger and longer timeline studies are needed to understand reinfection risks. With the ongoing distribution of the SARS-CoV-2 vaccines to provide protection, the understanding of the possibility for SARS-CoV-2 reinfection remains critical. Abbreviations CDC: Centers for Disease ControlSARS-CoV-2: Severe acute respiratory syndrome coronavirus 2COVID-19: Coronavirus disease 2019RT-PCR: Reverse Transcription Polymerase Chain ReactionPASC: Post-Acute Sequelae of SARS-CoV-2 infection.
Keywords: COVID-19; COVID-19 immunity; COVID-19 vaccination; SARS-CoV-2; reinfection.