tetano
Editor, Senior Moderator
J Community Hosp Intern Med Perspect
. 2022 Jul 4;12(4):7-13.
doi: 10.55729/2000-9666.1087. eCollection 2022.
A Case of Adult Multisystem Inflammatory Syndrome Following COVID-19 Vaccine
Meghan Brown[SUP] 1 [/SUP], Nika Z Garbajs[SUP] 1 [/SUP], Simon Zec[SUP] 1 [/SUP], Hisham Mushtaq[SUP] 2 [/SUP], Anwar Khedr[SUP] 2 [/SUP], Abbas B Jama[SUP] 2 [/SUP], Ibtisam Rauf[SUP] 3 [/SUP], Mikael Mir[SUP] 4 [/SUP], Aishwarya R Korsapati[SUP] 5 [/SUP], Shikha Jain[SUP] 6 [/SUP], Thoyaja Koritala[SUP] 2 [/SUP], Ramesh Adhikari[SUP] 7 [/SUP], Amos Lal[SUP] 1 [/SUP], Ognjen Gajic[SUP] 1 [/SUP], Juan Pablo Domecq[SUP] 1 [/SUP], Sarah Goksoy[SUP] 8 [/SUP], Brian Bartlett[SUP] 2 [/SUP], Amit Sharma[SUP] 9 [/SUP], Nitesh Kumar Jain[SUP] 2 [/SUP], Syed Anjum Khan[SUP] 2 [/SUP]
Affiliations
Abstract
Multisystem inflammatory syndrome is a life-threatening condition associated with elevated inflammatory markers and multiple organ injury. A diagnosis of exclusion, it has been reported after severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV-2) in children and adults; recently it has been described in some post-COVID-19 vaccinated individuals. The prognosis with supportive care and immunomodulatory therapy is good, although some individuals may require treatment in the intensive care unit (ICU). Here we report a case of a 58-year-old man who developed multi-organ failure after receiving the second dose of the Moderna mRNA-1273 COVID-19 vaccine. He required critical organ support in the ICU. An extensive workup was done to rule out alternative infectious and inflammatory processes. Following a period of gradual in-hospital convalescence, our patient made a full recovery. To our knowledge, this is the first comprehensively described case of multisystem inflammatory syndrome associated with Moderna mRNA-1273 COVID-19 vaccine in an adult over 50 years of age.
Keywords: Acute tubular necrosis (ATN); COVID-19 vaccine; Immunological products and vaccines; Intensive care; Multisystem inflammatory syndrome in adults (MIS-A); Multisystem inflammatory syndrome in vaccinated individuals (MIS-V); Unwanted effects/Adverse reactions; Vaccination/immunization.
. 2022 Jul 4;12(4):7-13.
doi: 10.55729/2000-9666.1087. eCollection 2022.
A Case of Adult Multisystem Inflammatory Syndrome Following COVID-19 Vaccine
Meghan Brown[SUP] 1 [/SUP], Nika Z Garbajs[SUP] 1 [/SUP], Simon Zec[SUP] 1 [/SUP], Hisham Mushtaq[SUP] 2 [/SUP], Anwar Khedr[SUP] 2 [/SUP], Abbas B Jama[SUP] 2 [/SUP], Ibtisam Rauf[SUP] 3 [/SUP], Mikael Mir[SUP] 4 [/SUP], Aishwarya R Korsapati[SUP] 5 [/SUP], Shikha Jain[SUP] 6 [/SUP], Thoyaja Koritala[SUP] 2 [/SUP], Ramesh Adhikari[SUP] 7 [/SUP], Amos Lal[SUP] 1 [/SUP], Ognjen Gajic[SUP] 1 [/SUP], Juan Pablo Domecq[SUP] 1 [/SUP], Sarah Goksoy[SUP] 8 [/SUP], Brian Bartlett[SUP] 2 [/SUP], Amit Sharma[SUP] 9 [/SUP], Nitesh Kumar Jain[SUP] 2 [/SUP], Syed Anjum Khan[SUP] 2 [/SUP]
Affiliations
- PMID: 36262897
- PMCID: PMC9533789
- DOI: 10.55729/2000-9666.1087
Abstract
Multisystem inflammatory syndrome is a life-threatening condition associated with elevated inflammatory markers and multiple organ injury. A diagnosis of exclusion, it has been reported after severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV-2) in children and adults; recently it has been described in some post-COVID-19 vaccinated individuals. The prognosis with supportive care and immunomodulatory therapy is good, although some individuals may require treatment in the intensive care unit (ICU). Here we report a case of a 58-year-old man who developed multi-organ failure after receiving the second dose of the Moderna mRNA-1273 COVID-19 vaccine. He required critical organ support in the ICU. An extensive workup was done to rule out alternative infectious and inflammatory processes. Following a period of gradual in-hospital convalescence, our patient made a full recovery. To our knowledge, this is the first comprehensively described case of multisystem inflammatory syndrome associated with Moderna mRNA-1273 COVID-19 vaccine in an adult over 50 years of age.
Keywords: Acute tubular necrosis (ATN); COVID-19 vaccine; Immunological products and vaccines; Intensive care; Multisystem inflammatory syndrome in adults (MIS-A); Multisystem inflammatory syndrome in vaccinated individuals (MIS-V); Unwanted effects/Adverse reactions; Vaccination/immunization.