tetano
Editor, Senior Moderator
J Clin Virol. 2020 Mar 29;126:104338. doi: 10.1016/j.jcv.2020.104338. [Epub ahead of print]
Severity of coronavirus respiratory tract infections in adults admitted to acute care in Toronto, Ontario.
Kozak R[SUP]1[/SUP], Prost K[SUP]2[/SUP], Yip L[SUP]2[/SUP], Williams V[SUP]3[/SUP], Leis JA[SUP]4[/SUP], Mubareka S[SUP]5[/SUP].
Author information
Abstract
BACKGROUND:
The World Health Organization has highlighted the need for improved surveillance and understanding of the health burden imposed by non-influenza RNA respiratory viruses. Human coronaviruses (CoVs) are a major cause of respiratory and gastrointestinal tract infections with associated morbidity and mortality.
OBJECTIVES:
The objective of our study was to characterize the epidemiology of CoVs in our tertiary care centre, and identify clinical correlates of disease severity.
STUDY DESIGN:
A cross-sectional study was performed of 226 patients admitted with confirmed CoV respiratory tract infection between 2010 and 2016. Variables consistent with a severe disease burden were evaluated including symptoms, length of stay, intensive care unit (ICU) admission and mortality.
RESULTS:
CoVs represented 11.3% of all positive respiratory virus samples and OC43 was the most commonly identified CoV. The majority of infections were community-associated while 21.6% were considered nosocomial. The average length of stay was 11.8 days with 17.3% of patients requiring ICU admission and an all-cause mortality of 7%. In a multivariate model, female gender and smoking were associated with increased likelihood of admission to ICU or death.
CONCLUSION:
This study highlights the significant burden of CoVs and justifies the need for surveillance in the acute care setting.
Copyright ? 2020. Published by Elsevier B.V.
KEYWORDS:
Coronavirus; Disease burden; Prevalence; Respiratory tract infection; Risk factors
PMID:32278299DOI:10.1016/j.jcv.2020.104338
Severity of coronavirus respiratory tract infections in adults admitted to acute care in Toronto, Ontario.
Kozak R[SUP]1[/SUP], Prost K[SUP]2[/SUP], Yip L[SUP]2[/SUP], Williams V[SUP]3[/SUP], Leis JA[SUP]4[/SUP], Mubareka S[SUP]5[/SUP].
Author information
Abstract
BACKGROUND:
The World Health Organization has highlighted the need for improved surveillance and understanding of the health burden imposed by non-influenza RNA respiratory viruses. Human coronaviruses (CoVs) are a major cause of respiratory and gastrointestinal tract infections with associated morbidity and mortality.
OBJECTIVES:
The objective of our study was to characterize the epidemiology of CoVs in our tertiary care centre, and identify clinical correlates of disease severity.
STUDY DESIGN:
A cross-sectional study was performed of 226 patients admitted with confirmed CoV respiratory tract infection between 2010 and 2016. Variables consistent with a severe disease burden were evaluated including symptoms, length of stay, intensive care unit (ICU) admission and mortality.
RESULTS:
CoVs represented 11.3% of all positive respiratory virus samples and OC43 was the most commonly identified CoV. The majority of infections were community-associated while 21.6% were considered nosocomial. The average length of stay was 11.8 days with 17.3% of patients requiring ICU admission and an all-cause mortality of 7%. In a multivariate model, female gender and smoking were associated with increased likelihood of admission to ICU or death.
CONCLUSION:
This study highlights the significant burden of CoVs and justifies the need for surveillance in the acute care setting.
Copyright ? 2020. Published by Elsevier B.V.
KEYWORDS:
Coronavirus; Disease burden; Prevalence; Respiratory tract infection; Risk factors
PMID:32278299DOI:10.1016/j.jcv.2020.104338