tetano
Editor, Senior Moderator
J Clin Virol. 2020 Apr 14;127:104370. doi: 10.1016/j.jcv.2020.104370. [Epub ahead of print]
Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19.
Liu F[SUP]1[/SUP], Li L[SUP]1[/SUP], Xu M[SUP]1[/SUP], Wu J[SUP]1[/SUP], Luo D[SUP]1[/SUP], Zhu Y[SUP]1[/SUP], Li B[SUP]1[/SUP], Song X[SUP]1[/SUP], Zhou X[SUP]2[/SUP].
Author information
Abstract
BACKGROUND:
The inflammatory response plays a critical role in coronavirus disease 2019 (COVID-19), and inflammatory cytokine storm increases the severity of COVID-19.
OBJECTIVE:
To investigate the ability of interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin (PCT) to predict mild and severe cases of COVID-19.
STUDY DESIGN:
This retrospective cohort study included 140 patients diagnosed with COVID-19 from January 18, 2020, to March 12, 2020. The study population was divided into two groups according to disease severity: a mild group (MG) (n = 107) and a severe group (SG) (n = 33). Data on demographic characteristics, baseline clinical characteristics, and the levels of IL-6, CRP, and PCT on admission were collected.
RESULTS:
Among the 140 patients, the levels of IL-6, CRP, and PCT increased in 95 (67.9 %), 91 (65.0 %), and 8 (5.7 %) patients on admission, respectively. The proportion of patients with increased IL-6, CRP, and PCT levels was significantly higher in the SG than in the MG. Cox proportional hazard model showed that IL-6 and CRP could be used as independent factors to predict the severity of COVID-19. Furthermore, patients with IL-6 > 32.1 pg/mL or CRP > 41.8 mg/L were more likely to have severe complications.
CONCLUSION:
The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19.
Copyright ? 2020 Elsevier B.V. All rights reserved.
KEYWORDS:
C-reactive protein; COVID-19; Interleukin-6; Procalcitonin; Prognosis
PMID:32344321DOI:10.1016/j.jcv.2020.104370
Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19.
Liu F[SUP]1[/SUP], Li L[SUP]1[/SUP], Xu M[SUP]1[/SUP], Wu J[SUP]1[/SUP], Luo D[SUP]1[/SUP], Zhu Y[SUP]1[/SUP], Li B[SUP]1[/SUP], Song X[SUP]1[/SUP], Zhou X[SUP]2[/SUP].
Author information
Abstract
BACKGROUND:
The inflammatory response plays a critical role in coronavirus disease 2019 (COVID-19), and inflammatory cytokine storm increases the severity of COVID-19.
OBJECTIVE:
To investigate the ability of interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin (PCT) to predict mild and severe cases of COVID-19.
STUDY DESIGN:
This retrospective cohort study included 140 patients diagnosed with COVID-19 from January 18, 2020, to March 12, 2020. The study population was divided into two groups according to disease severity: a mild group (MG) (n = 107) and a severe group (SG) (n = 33). Data on demographic characteristics, baseline clinical characteristics, and the levels of IL-6, CRP, and PCT on admission were collected.
RESULTS:
Among the 140 patients, the levels of IL-6, CRP, and PCT increased in 95 (67.9 %), 91 (65.0 %), and 8 (5.7 %) patients on admission, respectively. The proportion of patients with increased IL-6, CRP, and PCT levels was significantly higher in the SG than in the MG. Cox proportional hazard model showed that IL-6 and CRP could be used as independent factors to predict the severity of COVID-19. Furthermore, patients with IL-6 > 32.1 pg/mL or CRP > 41.8 mg/L were more likely to have severe complications.
CONCLUSION:
The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19.
Copyright ? 2020 Elsevier B.V. All rights reserved.
KEYWORDS:
C-reactive protein; COVID-19; Interleukin-6; Procalcitonin; Prognosis
PMID:32344321DOI:10.1016/j.jcv.2020.104370