tetano
Editor, Senior Moderator
J Clin Virol. 2020 Apr 10;127:104356. doi: 10.1016/j.jcv.2020.104356. [Epub ahead of print]
Clinical characteristics and risk assessment of newborns born to mothers with COVID-19.
Yang P[SUP]1[/SUP], Wang X[SUP]1[/SUP], Liu P[SUP]1[/SUP], Wei C[SUP]1[/SUP], He B[SUP]1[/SUP], Zheng J[SUP]1[/SUP], Zhao D[SUP]2[/SUP].
Author information
Abstract
BACKGROUND:
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is causing an outbreak of pneumonia in Wuhan, Hubei Province, China, and other international areas.
OBJECTIVE:
Here, we report the clinical characteristics of the newborns delivered by SARS-CoV-2 infected pregnant women.
METHODS:
We prospectively collected and analyzed the clinical features, laboratory data and outcomes of 7 newborns delivered by SARS-CoV-2 infected pregnant women in Zhongnan Hospital of Wuhan University during January 20 to January 29, 2020.
RESULTS:
4 of the 7 newborns were late preterm with gestational age between 36 weeks and 37 weeks, and the other 3 were full-term infants. The average birth weight was 2096 ? 660 g. All newborns were born without asphyxia. 2 premature infants performed mild grunting after birth, but relieved rapidly with non-invasive continuous positive airway pressure (nCPAP) ventilation. 3 cases had chest X-ray, 1 was normal and 2 who were supported by nCPAP presented mild neonatal respiratory distress syndrome (NRDS). Samples of pharyngeal swab in 6 cases, amniotic fluid and umbilical cord blood in 4 cases were tested by qRT-PCR, and there was no positive result of SARS-CoV-2 nucleic acid in all cases.
CONCLUSIONS:
The current data show that the infection of SARS-CoV-2 in late pregnant women does not cause adverse outcomes in their newborns, however, it is necessary to separate newborns from mothers immediately to avoid the potential threats.
Copyright ? 2020 Elsevier B.V. All rights reserved.
KEYWORDS:
COVID-19; Clinical features; Mother-to-child vertical transmission; Newborn; Pregnant woman; SARS-CoV-2
PMID:32302955DOI:10.1016/j.jcv.2020.104356
Clinical characteristics and risk assessment of newborns born to mothers with COVID-19.
Yang P[SUP]1[/SUP], Wang X[SUP]1[/SUP], Liu P[SUP]1[/SUP], Wei C[SUP]1[/SUP], He B[SUP]1[/SUP], Zheng J[SUP]1[/SUP], Zhao D[SUP]2[/SUP].
Author information
Abstract
BACKGROUND:
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is causing an outbreak of pneumonia in Wuhan, Hubei Province, China, and other international areas.
OBJECTIVE:
Here, we report the clinical characteristics of the newborns delivered by SARS-CoV-2 infected pregnant women.
METHODS:
We prospectively collected and analyzed the clinical features, laboratory data and outcomes of 7 newborns delivered by SARS-CoV-2 infected pregnant women in Zhongnan Hospital of Wuhan University during January 20 to January 29, 2020.
RESULTS:
4 of the 7 newborns were late preterm with gestational age between 36 weeks and 37 weeks, and the other 3 were full-term infants. The average birth weight was 2096 ? 660 g. All newborns were born without asphyxia. 2 premature infants performed mild grunting after birth, but relieved rapidly with non-invasive continuous positive airway pressure (nCPAP) ventilation. 3 cases had chest X-ray, 1 was normal and 2 who were supported by nCPAP presented mild neonatal respiratory distress syndrome (NRDS). Samples of pharyngeal swab in 6 cases, amniotic fluid and umbilical cord blood in 4 cases were tested by qRT-PCR, and there was no positive result of SARS-CoV-2 nucleic acid in all cases.
CONCLUSIONS:
The current data show that the infection of SARS-CoV-2 in late pregnant women does not cause adverse outcomes in their newborns, however, it is necessary to separate newborns from mothers immediately to avoid the potential threats.
Copyright ? 2020 Elsevier B.V. All rights reserved.
KEYWORDS:
COVID-19; Clinical features; Mother-to-child vertical transmission; Newborn; Pregnant woman; SARS-CoV-2
PMID:32302955DOI:10.1016/j.jcv.2020.104356