tetano
Editor, Senior Moderator
J Clin Rheumatol
. 2023 Nov 8.
doi: 10.1097/RHU.0000000000002038. Online ahead of print. Factors Associated With Mortality in Patients With Immune-Mediated Rheumatic Diseases and COVID-19 From Latin America: Data From Argentina, Mexico, and Brazil
Carolina Ayelen Isnardi[SUP] 1 [/SUP], Deshire Alpizar-Rodriguez[SUP] 2 [/SUP], Débora Cerqueira Calderaro[SUP] 3 [/SUP], Claudia Diniz Lopes Marques[SUP] 4 [/SUP], Guillermo Javier Pons-Estel[SUP] 1 [/SUP], Ricardo Machado Xavier[SUP] 5 [/SUP], Verónica Saurit[SUP] 6 [/SUP], Cecilia Nora Pisoni[SUP] 7 [/SUP], Yohana Soledad Tissera, Maria Eugenia D'Angelo Exeni[SUP] 8 [/SUP], Paula Alba[SUP] 9 [/SUP], Dora Pereira[SUP] 10 [/SUP], Carla Andrea Gobbi[SUP] 11 [/SUP], Maria Julieta Gamba[SUP] 12 [/SUP], María Agustina Alfaro[SUP] 1 [/SUP], Belén María Virasoro[SUP] 1 [/SUP], Iris Jazmín Colunga-Pedraza[SUP] 13 [/SUP], Fedra Irazoque-Palazuelos[SUP] 14 [/SUP], Greta Reyes-Cordero[SUP] 15 [/SUP], Tatiana S Rodriguez-Reyna[SUP] 16 [/SUP], Jose Antonio Veloz-Aranda[SUP] 17 [/SUP], Cassandra Michele Skinner-Taylor[SUP] 13 [/SUP], Ingrid Maribel Juárez-Mora[SUP] 18 [/SUP], Luis H Silveira[SUP] 19 [/SUP], Cesar Francisco Pacheco Tena[SUP] 20 [/SUP], Daniel Xavier Xibille-Friedmann[SUP] 21 [/SUP], Gilda Aparecida Ferreira[SUP] 3 [/SUP], Adriana Maria Kakehasi[SUP] 3 [/SUP], Marcelo Medeiros Pinheiro[SUP] 22 [/SUP], Ana Paula Monteiro Gomides[SUP] 23 [/SUP], Gecilmara Cristina Salviato Pileggi[SUP] 22 [/SUP], Licia Maria Henrique da Mota[SUP] 24 [/SUP], Edgard Torres Dos Reis-Neto[SUP] 22 [/SUP], Sandra Lúcia Euzébio Ribeiro[SUP] 25 [/SUP], Lilian David de Azevedo Valadares[SUP] 26 [/SUP], Marco Ulises Martínez-Martínez[SUP] 27 [/SUP]
Affiliations
Objective: To describe characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with rheumatic immune-mediated inflammatory diseases (IMIDs) from Argentina, Mexico and Brazil, and to assess factors associated with mortality in this population.
Methods: Data from 3 national registries, SAR-COVID (Argentina), CMR-COVID (Mexico), and ReumaCoV-Brasil (Brazil), were combined. Adult patients with IMIDs and SARS-CoV-2 infection were recruited. Sociodemographic data, comorbidities, IMID clinical characteristics and treatment, and SARS-CoV-2 infection presentation and outcomes were recorded.
Results: A total of 4827 individuals were included: 2542 (52.7%) from SAR-COVID, 1167 (24.2%) from CMR-COVID, and 1118 (23.1%) from ReumaCoV-Brasil. Overall, 82.1% were female with a mean age of 49.7 (SD, 14.3) years; 22.7% of the patients were hospitalized, and 5.3% died because of COVID-19 (coronavirus disease 2019). Argentina and Brazil had both 4% of mortality and Mexico 9.4%. In the multivariable analysis, older age (≥60 years; odds ratio [OR], 7.4; 95% confidence interval [CI], 4.6-12.4), male sex (OR, 1.5; 95% CI, 1.1-2.1), living in Mexico (OR, 3.0; 95% CI, 2.0-4.4), comorbidity count (1 comorbidity: OR, 1.5; 95% CI, 1.0-2.1), diagnosis of connective tissue disease or vasculitis (OR, 1.8; 95% CI, 1.3-2.4), and other diseases (OR, 2.6; 95% CI, 1.6-4.1) compared with inflammatory joint disease, high disease activity (OR, 4.2; 95% CI, 2.5-7.0), and treatment with glucocorticoids (OR, 1.9; 95% CI, 1.4-2.5) or rituximab (OR, 4.2; 95% CI, 2.7-6.6) were associated with mortality.
Conclusions: Mortality in patients with IMIDs was particularly high in Mexicans. Ethnic, environmental, societal factors, and different COVID-19 mitigation measures adopted have probably influenced these results.
. 2023 Nov 8.
doi: 10.1097/RHU.0000000000002038. Online ahead of print. Factors Associated With Mortality in Patients With Immune-Mediated Rheumatic Diseases and COVID-19 From Latin America: Data From Argentina, Mexico, and Brazil
Carolina Ayelen Isnardi[SUP] 1 [/SUP], Deshire Alpizar-Rodriguez[SUP] 2 [/SUP], Débora Cerqueira Calderaro[SUP] 3 [/SUP], Claudia Diniz Lopes Marques[SUP] 4 [/SUP], Guillermo Javier Pons-Estel[SUP] 1 [/SUP], Ricardo Machado Xavier[SUP] 5 [/SUP], Verónica Saurit[SUP] 6 [/SUP], Cecilia Nora Pisoni[SUP] 7 [/SUP], Yohana Soledad Tissera, Maria Eugenia D'Angelo Exeni[SUP] 8 [/SUP], Paula Alba[SUP] 9 [/SUP], Dora Pereira[SUP] 10 [/SUP], Carla Andrea Gobbi[SUP] 11 [/SUP], Maria Julieta Gamba[SUP] 12 [/SUP], María Agustina Alfaro[SUP] 1 [/SUP], Belén María Virasoro[SUP] 1 [/SUP], Iris Jazmín Colunga-Pedraza[SUP] 13 [/SUP], Fedra Irazoque-Palazuelos[SUP] 14 [/SUP], Greta Reyes-Cordero[SUP] 15 [/SUP], Tatiana S Rodriguez-Reyna[SUP] 16 [/SUP], Jose Antonio Veloz-Aranda[SUP] 17 [/SUP], Cassandra Michele Skinner-Taylor[SUP] 13 [/SUP], Ingrid Maribel Juárez-Mora[SUP] 18 [/SUP], Luis H Silveira[SUP] 19 [/SUP], Cesar Francisco Pacheco Tena[SUP] 20 [/SUP], Daniel Xavier Xibille-Friedmann[SUP] 21 [/SUP], Gilda Aparecida Ferreira[SUP] 3 [/SUP], Adriana Maria Kakehasi[SUP] 3 [/SUP], Marcelo Medeiros Pinheiro[SUP] 22 [/SUP], Ana Paula Monteiro Gomides[SUP] 23 [/SUP], Gecilmara Cristina Salviato Pileggi[SUP] 22 [/SUP], Licia Maria Henrique da Mota[SUP] 24 [/SUP], Edgard Torres Dos Reis-Neto[SUP] 22 [/SUP], Sandra Lúcia Euzébio Ribeiro[SUP] 25 [/SUP], Lilian David de Azevedo Valadares[SUP] 26 [/SUP], Marco Ulises Martínez-Martínez[SUP] 27 [/SUP]
Affiliations
- PMID: 37936271
- DOI: 10.1097/RHU.0000000000002038
Objective: To describe characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with rheumatic immune-mediated inflammatory diseases (IMIDs) from Argentina, Mexico and Brazil, and to assess factors associated with mortality in this population.
Methods: Data from 3 national registries, SAR-COVID (Argentina), CMR-COVID (Mexico), and ReumaCoV-Brasil (Brazil), were combined. Adult patients with IMIDs and SARS-CoV-2 infection were recruited. Sociodemographic data, comorbidities, IMID clinical characteristics and treatment, and SARS-CoV-2 infection presentation and outcomes were recorded.
Results: A total of 4827 individuals were included: 2542 (52.7%) from SAR-COVID, 1167 (24.2%) from CMR-COVID, and 1118 (23.1%) from ReumaCoV-Brasil. Overall, 82.1% were female with a mean age of 49.7 (SD, 14.3) years; 22.7% of the patients were hospitalized, and 5.3% died because of COVID-19 (coronavirus disease 2019). Argentina and Brazil had both 4% of mortality and Mexico 9.4%. In the multivariable analysis, older age (≥60 years; odds ratio [OR], 7.4; 95% confidence interval [CI], 4.6-12.4), male sex (OR, 1.5; 95% CI, 1.1-2.1), living in Mexico (OR, 3.0; 95% CI, 2.0-4.4), comorbidity count (1 comorbidity: OR, 1.5; 95% CI, 1.0-2.1), diagnosis of connective tissue disease or vasculitis (OR, 1.8; 95% CI, 1.3-2.4), and other diseases (OR, 2.6; 95% CI, 1.6-4.1) compared with inflammatory joint disease, high disease activity (OR, 4.2; 95% CI, 2.5-7.0), and treatment with glucocorticoids (OR, 1.9; 95% CI, 1.4-2.5) or rituximab (OR, 4.2; 95% CI, 2.7-6.6) were associated with mortality.
Conclusions: Mortality in patients with IMIDs was particularly high in Mexicans. Ethnic, environmental, societal factors, and different COVID-19 mitigation measures adopted have probably influenced these results.