tetano
Editor, Senior Moderator
J Clin Pharm Ther
. 2020 Oct 31.
doi: 10.1111/jcpt.13305. Online ahead of print.
Observational study of the effects of Favipiravir vs Lopinavir/Ritonavir on clinical outcomes in critically Ill patients with COVID-19
Havva Kocayiğit[SUP] 1 [/SUP], Kezban ?zmen S?ner[SUP] 2 [/SUP], Yakup Tomak[SUP] 1 [/SUP], G?rkan Demir[SUP] 1 [/SUP], Sel?uk Yaylacı[SUP] 3 [/SUP], Hamad Dheir[SUP] 4 [/SUP], Ertuğrul G??l?[SUP] 5 [/SUP], Ali Fuat Erdem[SUP] 1 [/SUP]
Affiliations
Abstract
What is known and objectives: In November 2019, several patients were diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan, China. So far, there are no specific treatments with proven high efficacy in patients with SARS-CoV-2. Presently, several drugs, such as hydroxychloroquine, ribavirin, favipiravir (FVP), lopinavir/ritonavir (LPV/r), remdesivir and oseltamivir, have been suggested as effective treatments for SARS-CoV-2. The aim of this study was to describe the clinical experience with FPV and LPV/r in critically ill patients with COVID-19 at Sakarya University Education and Research Hospital.
Methods: The study included 107 consecutive patients who had a laboratory confirmation of COVID-19 and were admitted to the intensive care unit (ICU) between 19 March and 19 May 2020. Follow-up continued through 30 May 2020 when the last observed patients were discharged.
Results and discussion: Of the 107 patients, 65 received FPV (Group FPV) and 42 received LPV/r (Group LPV/r). The two groups were similar in terms of demographic data and clinical findings. 43 (66.2%) of the 65 patients in the FPV group and 23 (54.8%) of the 42 patients in the LPV/r group died (p = 0.237). The median ICU stay was 6.6 (IQR, 3-10) days in the FPV group and 9 (IQR, 6-16) days in the LPV/r group, which was a statistically significant difference (p = 0.010).
What is new and conclusion: The length of hospital stay was significantly lower in the FVP group compared to the LPV/r group among patients who were discharged from the ICU. Although the analysis was done with a limited number of patients and the observed difference in mortality rate is of some concern, FVP treatment may be more beneficial than LPV/r in terms of effective use in the ICU.
Keywords: COVİD-19; favipiravir; lopinavir.
. 2020 Oct 31.
doi: 10.1111/jcpt.13305. Online ahead of print.
Observational study of the effects of Favipiravir vs Lopinavir/Ritonavir on clinical outcomes in critically Ill patients with COVID-19
Havva Kocayiğit[SUP] 1 [/SUP], Kezban ?zmen S?ner[SUP] 2 [/SUP], Yakup Tomak[SUP] 1 [/SUP], G?rkan Demir[SUP] 1 [/SUP], Sel?uk Yaylacı[SUP] 3 [/SUP], Hamad Dheir[SUP] 4 [/SUP], Ertuğrul G??l?[SUP] 5 [/SUP], Ali Fuat Erdem[SUP] 1 [/SUP]
Affiliations
- PMID: 33128482
- DOI: 10.1111/jcpt.13305
Abstract
What is known and objectives: In November 2019, several patients were diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan, China. So far, there are no specific treatments with proven high efficacy in patients with SARS-CoV-2. Presently, several drugs, such as hydroxychloroquine, ribavirin, favipiravir (FVP), lopinavir/ritonavir (LPV/r), remdesivir and oseltamivir, have been suggested as effective treatments for SARS-CoV-2. The aim of this study was to describe the clinical experience with FPV and LPV/r in critically ill patients with COVID-19 at Sakarya University Education and Research Hospital.
Methods: The study included 107 consecutive patients who had a laboratory confirmation of COVID-19 and were admitted to the intensive care unit (ICU) between 19 March and 19 May 2020. Follow-up continued through 30 May 2020 when the last observed patients were discharged.
Results and discussion: Of the 107 patients, 65 received FPV (Group FPV) and 42 received LPV/r (Group LPV/r). The two groups were similar in terms of demographic data and clinical findings. 43 (66.2%) of the 65 patients in the FPV group and 23 (54.8%) of the 42 patients in the LPV/r group died (p = 0.237). The median ICU stay was 6.6 (IQR, 3-10) days in the FPV group and 9 (IQR, 6-16) days in the LPV/r group, which was a statistically significant difference (p = 0.010).
What is new and conclusion: The length of hospital stay was significantly lower in the FVP group compared to the LPV/r group among patients who were discharged from the ICU. Although the analysis was done with a limited number of patients and the observed difference in mortality rate is of some concern, FVP treatment may be more beneficial than LPV/r in terms of effective use in the ICU.
Keywords: COVİD-19; favipiravir; lopinavir.