tetano
Editor, Senior Moderator
J Clin Pharm Ther
. 2020 Nov 20.
doi: 10.1111/jcpt.13311. Online ahead of print.
Breakthrough venous thromboembolic events in five patients with COVID-19 on direct oral anticoagulants
Paul Lewis[SUP] 1 [/SUP], Jennifer L Tharp[SUP] 1 [/SUP]
Affiliations
Abstract
What is known and objective: Coronavirus disease 2019 (COVID-19) is associated with increased risk of venous thromboembolism (VTE). Guidance for VTE prophylaxis continues to evolve, including addressing direct oral anticoagulants (DOACs) continued upon hospitalization.
Case summaries: We present 5 patients hospitalized for COVID-19 while on DOACs. Four patients had atrial fibrillation and had a previous VTE. Four patients developed acute VTE and one developed stroke-like symptoms. Monitoring D-dimer assisted with the detection of VTE. Three patients died, and two were discharged alive.
What is new and conclusion: Therapeutic failure with DOACs appears to be commonplace in COVID-19. Further research is needed to determine whether there is an underlying cause to this association.
Keywords: SARS-CoV-2; factor Xa Inhibitors; heparin; low molecular weight; pulmonary embolism.
. 2020 Nov 20.
doi: 10.1111/jcpt.13311. Online ahead of print.
Breakthrough venous thromboembolic events in five patients with COVID-19 on direct oral anticoagulants
Paul Lewis[SUP] 1 [/SUP], Jennifer L Tharp[SUP] 1 [/SUP]
Affiliations
- PMID: 33217032
- DOI: 10.1111/jcpt.13311
Abstract
What is known and objective: Coronavirus disease 2019 (COVID-19) is associated with increased risk of venous thromboembolism (VTE). Guidance for VTE prophylaxis continues to evolve, including addressing direct oral anticoagulants (DOACs) continued upon hospitalization.
Case summaries: We present 5 patients hospitalized for COVID-19 while on DOACs. Four patients had atrial fibrillation and had a previous VTE. Four patients developed acute VTE and one developed stroke-like symptoms. Monitoring D-dimer assisted with the detection of VTE. Three patients died, and two were discharged alive.
What is new and conclusion: Therapeutic failure with DOACs appears to be commonplace in COVID-19. Further research is needed to determine whether there is an underlying cause to this association.
Keywords: SARS-CoV-2; factor Xa Inhibitors; heparin; low molecular weight; pulmonary embolism.